Excessive daytime sleepiness and topographic expansion of Lewy pathology.

Autor:	Abbott RD; From the Institute of Human Genomic Study (R.D.A., C.S.), Korea University College of Medicine, Ansan-si, Gyeonggi-do, South Korea; the Pacific Health Research and Education Institute (R.D.A., G.W.R., L.R.W., H.P.), Honolulu, HI; the Departments of Medicine (G.W.R.) and Pathology (J.H.U.-L.) and the John A. Hartford Foundation Center of Excellence in Geriatrics, Department of Geriatric Medicine (G.W.R., K.H.M., H.P.), John A. Burns School of Medicine, University of Hawaii, Honolulu; the Veterans Affairs Pacific Islands Health Care System (G.W.R., L.R.W., H.P.), Honolulu, HI; the Michael J. Crescenz Veterans Affairs Medical Center and the University of Pennsylvania Perelman School of Medicine (J.E.D.), Philadelphia; Kuakini Medical Center (K.H.M.), Honolulu, HI; the National Institute on Aging (L.J.L.), Bethesda, MD; and the San Francisco Veterans Affairs Medical Center and the Department of Neurology (C.M.T.), University of California-San Francisco. rda3e@virginia.edu., Ross GW; From the Institute of Human Genomic Study (R.D.A., C.S.), Korea University College of Medicine, Ansan-si, Gyeonggi-do, South Korea; the Pacific Health Research and Education Institute (R.D.A., G.W.R., L.R.W., H.P.), Honolulu, HI; the Departments of Medicine (G.W.R.) and Pathology (J.H.U.-L.) and the John A. Hartford Foundation Center of Excellence in Geriatrics, Department of Geriatric Medicine (G.W.R., K.H.M., H.P.), John A. Burns School of Medicine, University of Hawaii, Honolulu; the Veterans Affairs Pacific Islands Health Care System (G.W.R., L.R.W., H.P.), Honolulu, HI; the Michael J. Crescenz Veterans Affairs Medical Center and the University of Pennsylvania Perelman School of Medicine (J.E.D.), Philadelphia; Kuakini Medical Center (K.H.M.), Honolulu, HI; the National Institute on Aging (L.J.L.), Bethesda, MD; and the San Francisco Veterans Affairs Medical Center and the Department of Neurology (C.M.T.), University of California-San Francisco., Duda JE; From the Institute of Human Genomic Study (R.D.A., C.S.), Korea University College of Medicine, Ansan-si, Gyeonggi-do, South Korea; the Pacific Health Research and Education Institute (R.D.A., G.W.R., L.R.W., H.P.), Honolulu, HI; the Departments of Medicine (G.W.R.) and Pathology (J.H.U.-L.) and the John A. Hartford Foundation Center of Excellence in Geriatrics, Department of Geriatric Medicine (G.W.R., K.H.M., H.P.), John A. Burns School of Medicine, University of Hawaii, Honolulu; the Veterans Affairs Pacific Islands Health Care System (G.W.R., L.R.W., H.P.), Honolulu, HI; the Michael J. Crescenz Veterans Affairs Medical Center and the University of Pennsylvania Perelman School of Medicine (J.E.D.), Philadelphia; Kuakini Medical Center (K.H.M.), Honolulu, HI; the National Institute on Aging (L.J.L.), Bethesda, MD; and the San Francisco Veterans Affairs Medical Center and the Department of Neurology (C.M.T.), University of California-San Francisco., Shin C; From the Institute of Human Genomic Study (R.D.A., C.S.), Korea University College of Medicine, Ansan-si, Gyeonggi-do, South Korea; the Pacific Health Research and Education Institute (R.D.A., G.W.R., L.R.W., H.P.), Honolulu, HI; the Departments of Medicine (G.W.R.) and Pathology (J.H.U.-L.) and the John A. Hartford Foundation Center of Excellence in Geriatrics, Department of Geriatric Medicine (G.W.R., K.H.M., H.P.), John A. Burns School of Medicine, University of Hawaii, Honolulu; the Veterans Affairs Pacific Islands Health Care System (G.W.R., L.R.W., H.P.), Honolulu, HI; the Michael J. Crescenz Veterans Affairs Medical Center and the University of Pennsylvania Perelman School of Medicine (J.E.D.), Philadelphia; Kuakini Medical Center (K.H.M.), Honolulu, HI; the National Institute on Aging (L.J.L.), Bethesda, MD; and the San Francisco Veterans Affairs Medical Center and the Department of Neurology (C.M.T.), University of California-San Francisco., Uyehara-Lock JH; From the Institute of Human Genomic Study (R.D.A., C.S.), Korea University College of Medicine, Ansan-si, Gyeonggi-do, South Korea; the Pacific Health Research and Education Institute (R.D.A., G.W.R., L.R.W., H.P.), Honolulu, HI; the Departments of Medicine (G.W.R.) and Pathology (J.H.U.-L.) and the John A. Hartford Foundation Center of Excellence in Geriatrics, Department of Geriatric Medicine (G.W.R., K.H.M., H.P.), John A. Burns School of Medicine, University of Hawaii, Honolulu; the Veterans Affairs Pacific Islands Health Care System (G.W.R., L.R.W., H.P.), Honolulu, HI; the Michael J. Crescenz Veterans Affairs Medical Center and the University of Pennsylvania Perelman School of Medicine (J.E.D.), Philadelphia; Kuakini Medical Center (K.H.M.), Honolulu, HI; the National Institute on Aging (L.J.L.), Bethesda, MD; and the San Francisco Veterans Affairs Medical Center and the Department of Neurology (C.M.T.), University of California-San Francisco., Masaki KH; From the Institute of Human Genomic Study (R.D.A., C.S.), Korea University College of Medicine, Ansan-si, Gyeonggi-do, South Korea; the Pacific Health Research and Education Institute (R.D.A., G.W.R., L.R.W., H.P.), Honolulu, HI; the Departments of Medicine (G.W.R.) and Pathology (J.H.U.-L.) and the John A. Hartford Foundation Center of Excellence in Geriatrics, Department of Geriatric Medicine (G.W.R., K.H.M., H.P.), John A. Burns School of Medicine, University of Hawaii, Honolulu; the Veterans Affairs Pacific Islands Health Care System (G.W.R., L.R.W., H.P.), Honolulu, HI; the Michael J. Crescenz Veterans Affairs Medical Center and the University of Pennsylvania Perelman School of Medicine (J.E.D.), Philadelphia; Kuakini Medical Center (K.H.M.), Honolulu, HI; the National Institute on Aging (L.J.L.), Bethesda, MD; and the San Francisco Veterans Affairs Medical Center and the Department of Neurology (C.M.T.), University of California-San Francisco., Launer LJ; From the Institute of Human Genomic Study (R.D.A., C.S.), Korea University College of Medicine, Ansan-si, Gyeonggi-do, South Korea; the Pacific Health Research and Education Institute (R.D.A., G.W.R., L.R.W., H.P.), Honolulu, HI; the Departments of Medicine (G.W.R.) and Pathology (J.H.U.-L.) and the John A. Hartford Foundation Center of Excellence in Geriatrics, Department of Geriatric Medicine (G.W.R., K.H.M., H.P.), John A. Burns School of Medicine, University of Hawaii, Honolulu; the Veterans Affairs Pacific Islands Health Care System (G.W.R., L.R.W., H.P.), Honolulu, HI; the Michael J. Crescenz Veterans Affairs Medical Center and the University of Pennsylvania Perelman School of Medicine (J.E.D.), Philadelphia; Kuakini Medical Center (K.H.M.), Honolulu, HI; the National Institute on Aging (L.J.L.), Bethesda, MD; and the San Francisco Veterans Affairs Medical Center and the Department of Neurology (C.M.T.), University of California-San Francisco., White LR; From the Institute of Human Genomic Study (R.D.A., C.S.), Korea University College of Medicine, Ansan-si, Gyeonggi-do, South Korea; the Pacific Health Research and Education Institute (R.D.A., G.W.R., L.R.W., H.P.), Honolulu, HI; the Departments of Medicine (G.W.R.) and Pathology (J.H.U.-L.) and the John A. Hartford Foundation Center of Excellence in Geriatrics, Department of Geriatric Medicine (G.W.R., K.H.M., H.P.), John A. Burns School of Medicine, University of Hawaii, Honolulu; the Veterans Affairs Pacific Islands Health Care System (G.W.R., L.R.W., H.P.), Honolulu, HI; the Michael J. Crescenz Veterans Affairs Medical Center and the University of Pennsylvania Perelman School of Medicine (J.E.D.), Philadelphia; Kuakini Medical Center (K.H.M.), Honolulu, HI; the National Institute on Aging (L.J.L.), Bethesda, MD; and the San Francisco Veterans Affairs Medical Center and the Department of Neurology (C.M.T.), University of California-San Francisco., Tanner CM; From the Institute of Human Genomic Study (R.D.A., C.S.), Korea University College of Medicine, Ansan-si, Gyeonggi-do, South Korea; the Pacific Health Research and Education Institute (R.D.A., G.W.R., L.R.W., H.P.), Honolulu, HI; the Departments of Medicine (G.W.R.) and Pathology (J.H.U.-L.) and the John A. Hartford Foundation Center of Excellence in Geriatrics, Department of Geriatric Medicine (G.W.R., K.H.M., H.P.), John A. Burns School of Medicine, University of Hawaii, Honolulu; the Veterans Affairs Pacific Islands Health Care System (G.W.R., L.R.W., H.P.), Honolulu, HI; the Michael J. Crescenz Veterans Affairs Medical Center and the University of Pennsylvania Perelman School of Medicine (J.E.D.), Philadelphia; Kuakini Medical Center (K.H.M.), Honolulu, HI; the National Institute on Aging (L.J.L.), Bethesda, MD; and the San Francisco Veterans Affairs Medical Center and the Department of Neurology (C.M.T.), University of California-San Francisco., Petrovitch H; From the Institute of Human Genomic Study (R.D.A., C.S.), Korea University College of Medicine, Ansan-si, Gyeonggi-do, South Korea; the Pacific Health Research and Education Institute (R.D.A., G.W.R., L.R.W., H.P.), Honolulu, HI; the Departments of Medicine (G.W.R.) and Pathology (J.H.U.-L.) and the John A. Hartford Foundation Center of Excellence in Geriatrics, Department of Geriatric Medicine (G.W.R., K.H.M., H.P.), John A. Burns School of Medicine, University of Hawaii, Honolulu; the Veterans Affairs Pacific Islands Health Care System (G.W.R., L.R.W., H.P.), Honolulu, HI; the Michael J. Crescenz Veterans Affairs Medical Center and the University of Pennsylvania Perelman School of Medicine (J.E.D.), Philadelphia; Kuakini Medical Center (K.H.M.), Honolulu, HI; the National Institute on Aging (L.J.L.), Bethesda, MD; and the San Francisco Veterans Affairs Medical Center and the Department of Neurology (C.M.T.), University of California-San Francisco.
Jazyk:	angličtina
Zdroj:	Neurology [Neurology] 2019 Oct 08; Vol. 93 (15), pp. e1425-e1432. Date of Electronic Publication: 2019 Aug 30.
DOI:	10.1212/WNL.0000000000008241
Abstrakt:	Objective: While excessive daytime sleepiness (EDS) can predate the clinical diagnosis of Parkinson disease (PD), associations with underlying PD pathogenesis are unknown. Our objective is to determine if EDS is related to brain Lewy pathology (LP), a marker of PD pathogenesis, using clinical assessments of EDS with postmortem follow-up. Methods: Identification of LP was based on staining for α-synuclein in multiple brain regions in a sample of 211 men. Data on EDS were collected at clinical examinations from 1991 to 1999 when participants were aged 72-97 years. Results: Although EDS was more common in the presence vs absence of LP ( p = 0.034), the association became stronger in neocortical regions. When LP was limited to the olfactory bulb, brainstem, and basal forebrain (Braak stages 1-4), frequency of EDS was 10% (4/40) vs 17.5% (20/114) in decedents without LP ( p = 0.258). In contrast, compared to the absence of LP, EDS frequency doubled (36.7% [11/30], p = 0.023) when LP reached the anterior cingulate gyrus, insula mesocortex, and midfrontal, midtemporal, and inferior parietal neocortex (Braak stage 5). With further infiltration into the primary motor and sensory neocortices (Braak stage 6), EDS frequency increased threefold (51.9% [14/27], p < 0.001). Findings were similar across sleep-related features and persisted after adjustment for age and other covariates, including the removal of PD and dementia with Lewy bodies. Conclusions: The association between EDS and PD includes relationships with extensive topographic LP expansion. The neocortex could be especially vulnerable to adverse relationships between sleep disorders and aggregation of misfolded α-synuclein and LP formation. (© 2019 American Academy of Neurology.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu