Role for calcium signaling in manganese neurotoxicity.

Autor: Ijomone OM; The Neuro- Lab, Department of Human Anatomy, Federal University of Technology Akure, Ondo, Nigeria. Electronic address: ijomoneom@futa.edu.ng., Aluko OM; Department of Physiology, Federal University of Technology Akure, Ondo, Nigeria., Okoh COA; The Neuro- Lab, Department of Human Anatomy, Federal University of Technology Akure, Ondo, Nigeria., Martins AC Jr; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, United States., Aschner M; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, United States. Electronic address: micheal.aschner@einstein.yu.edu.
Jazyk: angličtina
Zdroj: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2019 Dec; Vol. 56, pp. 146-155. Date of Electronic Publication: 2019 Aug 22.
DOI: 10.1016/j.jtemb.2019.08.006
Abstrakt: Background: Calcium is an essential macronutrient that is involved in many cellular processes. Homeostatic control of intracellular levels of calcium ions [Ca 2+ ] is vital to maintaining cellular structure and function. Several signaling molecules are involved in regulating Ca 2+ levels in cells and perturbation of calcium signaling processes is implicated in several neurodegenerative and neurologic conditions. Manganese [Mn] is a metal which is essential for basic physiological functions. However, overexposure to Mn from environmental contamination and workplace hazards is a global concern. Mn overexposure leads to its accumulation in several human organs particularly the brain. Mn accumulation in the brain results in a manganism, a Parkinsonian-like syndrome. Additionally, Mn is a risk factor for several neurodegenerative diseases including Parkinson's disease and Alzheimer's disease. Mn neurotoxicity also affects several neurotransmitter systems including dopaminergic, cholinergic and GABAergic. The mechanisms of Mn neurotoxicity are still being elucidated.
Aim: The review will highlight a potential role for calcium signaling molecules in the mechanisms of Mn neurotoxicity.
Conclusion: Ca 2+ regulation influences the neurodegenerative process and there is possible role for perturbed calcium signaling in Mn neurotoxicity. Mechanisms implicated in Mn-induced neurodegeneration include oxidative stress, generation of free radicals, and apoptosis. These are influenced by mitochondrial integrity which can be dependent on intracellular Ca 2+ homeostasis. Nevertheless, further elucidation of the direct effects of calcium signaling dysfunction and calcium-binding proteins activities in Mn neurotoxicity is required.
(Copyright © 2019. Published by Elsevier GmbH.)
Databáze: MEDLINE
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