A 10-year follow-up study of demographic and cardiometabolic factors in HIV-infected South Africans.

Autor:	Phalane E; Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa., Fourie CM; Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa; Medical Research Council Unit for Hypertension and Cardiovascular Disease, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa. Email: carla.fourie@nwu.ac.za., Mels CM; Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa; Medical Research Council Unit for Hypertension and Cardiovascular Disease, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa., Schutte AE; Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa; Medical Research Council Unit for Hypertension and Cardiovascular Disease, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
Jazyk:	angličtina
Zdroj:	Cardiovascular journal of Africa [Cardiovasc J Afr] 2019 Nov-Dec 23; Vol. 30 (6), pp. 352-360. Date of Electronic Publication: 2019 Aug 02.
DOI:	10.5830/CVJA-2019-034
Abstrakt:	Objectives: Understanding of the interplay between human immunodeficiency virus (HIV) and cardiovascular disease, especially in Africa, is limited to evidence from longitudinal studies. Therefore the demographic profile and cardiometabolic, renal and liver function of an HIV-infected South African population were profiled from 2005 to 2015. Methods: The study included 117 HIV-infected and 131 uninfected controls that were examined at baseline, five and 10 years. Results: Mortality rate declined from 24% (2005-2010) to 0% (2010-2015) after the introduction of ART. Longitudinal increases in C-reactive protein (p = 0.002), alanine transaminase (p = 0.006) and gamma-glutamyl transferase (p = 0.046) levels and estimated glomerular filtration rate (p < 0.001) were seen only in the HIV-infected group. This group also showed increased high-density lipoprotein cholesterol (HDL-C) (p < 0.001) and total cholesterol (p < 0.001) levels and decreased triglyceride:HDL-C (p = 0.011) levels. Low-density lipoprotein cholesterol decreased in both groups (p < 0.001). Conclusions: Despite trajectories of deranged lipid and inflammatory profiles, the cardiometabolic disease risk seems stable in HIV-infected South Africans. Inflammation and renal and liver function warrant regular monitoring.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu