| Autor: |
Tan CY; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy , The Ohio State University , Columbus , Ohio 43210 , United States., Wang F; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy , The Ohio State University , Columbus , Ohio 43210 , United States., Anaya-Eugenio GD; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy , The Ohio State University , Columbus , Ohio 43210 , United States., Gallucci JC; Department of Chemistry and Biochemistry , The Ohio State University , Columbus , Ohio 43210 , United States., Goughenour KD; Department of Microbiology , The Ohio State University , Columbus , Ohio 43210 , United States., Rappleye CA; Department of Microbiology , The Ohio State University , Columbus , Ohio 43210 , United States., Spjut RW; World Botanical Associates, Bakersfield , California , California 93380 , United States., Carcache de Blanco EJ; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy , The Ohio State University , Columbus , Ohio 43210 , United States.; Division of Pharmacy Practice and Science, College of Pharmacy , The Ohio State University , Columbus , Ohio 43210 , United States., Kinghorn AD; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy , The Ohio State University , Columbus , Ohio 43210 , United States., Rakotondraibe LH; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy , The Ohio State University , Columbus , Ohio 43210 , United States. |
| Abstrakt: |
Four new metabolites, 4- epi -citreoviridin ( 1 ), auransterol ( 3 ), and two analogues ( 2 and 4 ) of paxisterol ( 6 ), together with two known metabolites (15 R *,20 S *)-dihydroxyepisterol ( 5 ) and ( 6 ), were isolated from cultures of the fungal associate, Penicillium aurantiacobrunneum , of the lichen Niebla homalea , endemic to California and Baja California. The structures of all compounds were determined by comprehensive spectroscopic and spectrometric methods, as well as single-crystal X-ray diffraction for the determination of the absolute configuration of 3 . Compound 1 showed selective cytotoxicity toward MCF-7 breast and A2780 ovarian cells with IC 50 values of 4.2 and 5.7 μM, respectively. |
