Hallmarks of Aging in the Liver.
| Autor: | Hunt NJ; ANZAC Research Institute, Aging and Alzheimer's Institute, Centre for Education and Research on Ageing, Concord Repatriation General Hospital, Concord, NSW, Australia.; The University of Sydney, Concord Clinical School, Sydney Medical School, Sydney, NSW, Australia.; The University of Sydney, Nutrition Ecology, Charles Perkins Centre, Sydney, NSW, Australia., Kang SWS; ANZAC Research Institute, Aging and Alzheimer's Institute, Centre for Education and Research on Ageing, Concord Repatriation General Hospital, Concord, NSW, Australia.; The University of Sydney, Nutrition Ecology, Charles Perkins Centre, Sydney, NSW, Australia., Lockwood GP; ANZAC Research Institute, Aging and Alzheimer's Institute, Centre for Education and Research on Ageing, Concord Repatriation General Hospital, Concord, NSW, Australia.; The University of Sydney, Nutrition Ecology, Charles Perkins Centre, Sydney, NSW, Australia., Le Couteur DG; ANZAC Research Institute, Aging and Alzheimer's Institute, Centre for Education and Research on Ageing, Concord Repatriation General Hospital, Concord, NSW, Australia.; The University of Sydney, Concord Clinical School, Sydney Medical School, Sydney, NSW, Australia.; The University of Sydney, Nutrition Ecology, Charles Perkins Centre, Sydney, NSW, Australia., Cogger VC; ANZAC Research Institute, Aging and Alzheimer's Institute, Centre for Education and Research on Ageing, Concord Repatriation General Hospital, Concord, NSW, Australia.; The University of Sydney, Concord Clinical School, Sydney Medical School, Sydney, NSW, Australia.; The University of Sydney, Nutrition Ecology, Charles Perkins Centre, Sydney, NSW, Australia. |
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| Jazyk: | angličtina |
| Zdroj: | Computational and structural biotechnology journal [Comput Struct Biotechnol J] 2019 Aug 07; Vol. 17, pp. 1151-1161. Date of Electronic Publication: 2019 Aug 07 (Print Publication: 2019). |
| DOI: | 10.1016/j.csbj.2019.07.021 |
| Abstrakt: | While the liver demonstrates remarkable resilience during aging, there is growing evidence that it undergoes all the cellular hallmarks of aging, which increases the risk of liver and systemic disease. The aging process in the liver is driven by alterations of the genome and epigenome that contribute to dysregulation of mitochondrial function and nutrient sensing pathways, leading to cellular senescence and low-grade inflammation. These changes promote multiple phenotypic changes in all liver cells (hepatocytes, liver sinusoidal endothelial, hepatic stellate and Küpffer cells) and impairment of hepatic function. In particular, age-related changes in the liver sinusoidal endothelial cells are a significant but under-recognized risk factor for the development of age-related cardiometabolic disease. Competing Interests: None. |
| Databáze: | MEDLINE |
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