Theory of Mind in Mild Cognitive Impairment - Relationship with Limbic Structures and Behavioural Change.

Autor:	Michaelian JC; Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Sydney 2050, Australia.; Brain and Mind Centre, University of Sydney, Sydney 2050, Australia.; School of Psychology, Faculty of Science, University of Sydney, Sydney 2006, Australia.; Charles Perkins Centre, University of Sydney, 2006, Australia., Mowszowski L; Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Sydney 2050, Australia.; Brain and Mind Centre, University of Sydney, Sydney 2050, Australia.; School of Psychology, Faculty of Science, University of Sydney, Sydney 2006, Australia., Guastella AJ; Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Sydney 2050, Australia.; Central Clinical School, Faculty of Medicine, University of Sydney, Sydney 2006, Australia., Henry JD; School of Psychology, University of Queensland, Brisbane 4072, Australia., Duffy S; Brain and Mind Centre, University of Sydney, Sydney 2050, Australia.; Charles Perkins Centre, University of Sydney, 2006, Australia.; Central Clinical School, Faculty of Medicine, University of Sydney, Sydney 2006, Australia., McCade D; Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Sydney 2050, Australia., Naismith SL; Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Sydney 2050, Australia.; Brain and Mind Centre, University of Sydney, Sydney 2050, Australia.; School of Psychology, Faculty of Science, University of Sydney, Sydney 2006, Australia.; Charles Perkins Centre, University of Sydney, 2006, Australia.
Jazyk:	angličtina
Zdroj:	Journal of the International Neuropsychological Society : JINS [J Int Neuropsychol Soc] 2019 Nov; Vol. 25 (10), pp. 1023-1034. Date of Electronic Publication: 2019 Aug 29.
DOI:	10.1017/S1355617719000870
Abstrakt:	Objectives: Older adults presenting with mild cognitive impairment (MCI) have a higher risk of developing dementia and also demonstrate impairments in social cognition. This study sought to establish whether in people with MCI, poorer theory of mind (ToM) was associated with volumetric changes in the amygdala and hippocampus, as well as early changes in behaviour. Methods: One hundred and fourteen people with MCI and fifty-two older adult controls completed the Reading the Mind in the Eyes Test (RMET), while close informants (e.g., spouse/family member/friend/carer) described any current behavioural changes using the Revised Cambridge Behavioural Inventory (CBI-R). A subsample of participants completed structural magnetic resonance imaging (MRI). Results: The MCI group showed poorer performance on all neuropsychological tests administered, and moderate reductions on the RMET compared to the control group (d = .44), with greater reduction observed in those with amnestic compared to non-amnestic MCI (p = .03). While a robust correlation was identified between poorer RMET performance and smaller hippocampal volume in the control group (ρ = .53, p = .01), this relationship was not apparent in the MCI group (ρ = .21, p = .11). In the MCI group, poorer RMET performance was associated with poorer everyday skills (ρ = -.26, p = .01) assessed by the CBI-R. Conclusions: Our findings cross-validate previous reports that social cognitive deficits in ToM are a feature of MCI and also suggest that disruptions to broader neural networks are likely to be implicated. Furthermore, ToM deficits in MCI are associated with a decline in everyday skills such as writing or paying bills.
Databáze:	MEDLINE
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