Copper-Bispidine Complexes: Synthesis and Complex Stability Study.

Autor: Medved'ko AV; Faculty of Chemistry and Faculty of Materials Science, Lomonosov Moscow State University, Leninskie Gory, 1, str. 3, Moscow 119991, Russia., Egorova BV; Faculty of Chemistry and Faculty of Materials Science, Lomonosov Moscow State University, Leninskie Gory, 1, str. 3, Moscow 119991, Russia., Komarova AA; Faculty of Chemistry and Faculty of Materials Science, Lomonosov Moscow State University, Leninskie Gory, 1, str. 3, Moscow 119991, Russia., Rakhimov RD; Faculty of Chemistry and Faculty of Materials Science, Lomonosov Moscow State University, Leninskie Gory, 1, str. 3, Moscow 119991, Russia., Krut'ko DP; Faculty of Chemistry and Faculty of Materials Science, Lomonosov Moscow State University, Leninskie Gory, 1, str. 3, Moscow 119991, Russia., Kalmykov SN; Faculty of Chemistry and Faculty of Materials Science, Lomonosov Moscow State University, Leninskie Gory, 1, str. 3, Moscow 119991, Russia., Vatsadze SZ; Faculty of Chemistry and Faculty of Materials Science, Lomonosov Moscow State University, Leninskie Gory, 1, str. 3, Moscow 119991, Russia.
Jazyk: angličtina
Zdroj: ACS omega [ACS Omega] 2016 Nov 08; Vol. 1 (5), pp. 854-867. Date of Electronic Publication: 2016 Nov 08 (Print Publication: 2016).
DOI: 10.1021/acsomega.6b00237
Abstrakt: A new series of dicarboxylic derivatives of bispidines have been synthesized to develop novel copper(II) complexes suitable as imaging agents for positron emission tomography. For characterization purposes, copper complexes of bispidines were synthesized in the pure form and in quantitative yields by neutralization of ligands with malachite. The formation of complexes and their stoichiometries were studied by potentiometric titration, cyclic voltammetry, and spectroscopic methods. The stability constants were found to be fairly suitable for copper cation fixation inside dianionic chelate molecules.
Competing Interests: The authors declare no competing financial interest.
Databáze: MEDLINE