The Levels of Vitamin D, Metalloproteinase-9 and Tissue Inhibitor Metalloproteinase-1 in COPD Patients, Healthy Smokers and Non-Smokers of Indonesian Citizens.

Autor:	Arbaningsih SR; Pulmonology Department, Faculty of Medicine, Muhammadiyah University of North Sumatra, Jl. Gedung Arca no.53 Medan Kota, Indonesia.; Pulmonology Department, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr.Mansyur no.5 Medan, Indonesia., Syarani F; Pulmonology Department, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr.Mansyur no.5 Medan, Indonesia., Ganie RA; Clinical Pathology Department, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr.Mansyur no.5 Medan, Indonesia., Lelo A; Pharmacology Department, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr.Mansyur no.5 Medan, Indonesia.
Jazyk:	angličtina
Zdroj:	Open access Macedonian journal of medical sciences [Open Access Maced J Med Sci] 2019 Jul 13; Vol. 7 (13), pp. 2123-2126. Date of Electronic Publication: 2019 Jul 13 (Print Publication: 2019).
DOI:	10.3889/oamjms.2019.612
Abstrakt:	Background: Exposure to cigarette smoke may stimulate the inflammatory response and activate polymorphonuclear leukocytes, thus resulting in secretion of cellular proteases. Vitamin D has the potential to modulate the inflammatory response to harmful particles in patients with Chronic Obstructive Pulmonary Disease (COPD). Aim: This study aimed to determine the levels of vitamin D, MMP-9, and TIMP-1 in COPD subjects, healthy smokers and nonsmokers of Indonesian citizens. Methods: Seventy-eight male subjects took part in this study. They comprised three groups, i.e. COPD (n = 26), healthy smokers (n = 25) and healthy non-smokers (n = 27). Serum 25(OHD) levels, MMP-9, and TIMP-1 concentrations measured by electrochemiluminescence binding assay (ECLIA) and enzyme-linked immunosorbent assay (ELISA). Results: The levels of vitamin D in COPD (21.96 ± 6.62ng/mL) and healthy smokers (27.87 ± 7.08 ng/mL) were significantly (p < 0.001) lower compared to that in healthy non-smokers (31.71 ± 9.24 ng/mL). On contrary, the levels of MMP-9 in COPD (11.98 ± 41.54 ng/mL) was significantly (p = 0.003) higher compared to that in healthy smokers (2.23 ± 3.39 ng/mL) and healthy non-smokers (0.89 ± 1.12 ng/mL). Whereas the levels of TIMP-1 in healthy smokers (24.64 ± 57.77 ng/mL) was significantly (p < 0.001) lower compared to that in COPD (58.40 ± 77.53 ng/mL) and healthy non-smokers (46,54 ± 71,48 ng/mL). Conclusion: The present study showed the lowest level of vitamin D, the highest level of MMP-9 and TIMP-1 in the COPD subjects.
Databáze:	MEDLINE
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