Role of Matrix Metalloproteinase-9 in Neonatal Hypoxic-Ischemic Encephalopathy.

Autor:	Salah MM; Department of Pediatrics, National Research Centre (NRC), Cairo, Egypt., Abdelmawla MA; Department of Pediatrics, National Research Centre (NRC), Cairo, Egypt., Eid SR; Department of Pediatrics, Research Institute of Ophthalmology Centre, Giza, Egypt., Hasanin RM; Department of Pediatrics, National Research Centre (NRC), Cairo, Egypt., Mostafa EA; Department of Pediatrics, National Research Centre (NRC), Cairo, Egypt., Abdelhameed MW; Department of Clinical Pathology, Shobra Hospial, Cairo, Egypt.
Jazyk:	angličtina
Zdroj:	Open access Macedonian journal of medical sciences [Open Access Maced J Med Sci] 2019 Jul 14; Vol. 7 (13), pp. 2114-2118. Date of Electronic Publication: 2019 Jul 14 (Print Publication: 2019).
DOI:	10.3889/oamjms.2019.618
Abstrakt:	Background: Neonatal encephalopathy is a heterogeneous syndrome characterised by signs of central nervous system dysfunction in the newborn. Matrix metalloproteinase-9(MMP-9) increases the blood-brain barrier permeability, and their inhibitors can reduce its damage. MMP-9 has been implicated specifically in cerebral ischemia. Aim: To measure serum MMP-9 in neonatal hypoxic-ischemic encephalopathy and evaluate its correlation to the severity of early prediction and treatment. Methods: its case-control study. The serum concentration of MMP-9 was determined by ELISA in 100 hypoxic neonates and 50 healthy neonates of matched age and sex who served as controls. Results: In our present study the serum MMP-9 level was significantly higher at p = 0.0001 in hypoxic-ischemic full-term newborns (176.7 ± 68.7 ng/ml)as compared to control newborn (69.4 ± 34.85 ng/ml)and it was significantly higher at p = 0.0075 in hypoxic-ischemic preterm newborn (171.2 ± 132.9 ng/ml) when compared to control newborn (72.54 ± 36.74 ng/ml), also MMP-9 was significantly higher at Sarnat stage III at p = 0.0001. Conclusion: Serum MMP-9 level was significantly higher in hypoxic-ischemic newborns, and significantly increased with severity, so we suggest that serum MMP-9 level is important for predicting neurological sequel and severity in neonatal encephalopathy.
Databáze:	MEDLINE
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