Optical assessment of alterations of microrheologic and microcirculation parameters in cardiovascular diseases.

Autor:	Lugovtsov AE; Department of Physics of Lomonosov Moscow State University, 1-2 Leninskie Gory, Moscow, 119991, Russia.; International Laser Center of Lomonosov Moscow State University, 1-62 Leninskie Gory, Moscow, 119991, Russia., Gurfinkel YI; Medical Research and Education Center of Lomonosov Moscow State University, 27-10 Lomonosovsky pr-t, Moscow, 119991, Russia., Ermolinskiy PB; Department of Physics of Lomonosov Moscow State University, 1-2 Leninskie Gory, Moscow, 119991, Russia., Maslyanitsina AI; Department of Physics of Lomonosov Moscow State University, 1-2 Leninskie Gory, Moscow, 119991, Russia., Dyachuk LI; Medical Research and Education Center of Lomonosov Moscow State University, 27-10 Lomonosovsky pr-t, Moscow, 119991, Russia., Priezzhev AV; Department of Physics of Lomonosov Moscow State University, 1-2 Leninskie Gory, Moscow, 119991, Russia.; International Laser Center of Lomonosov Moscow State University, 1-62 Leninskie Gory, Moscow, 119991, Russia.
Jazyk:	angličtina
Zdroj:	Biomedical optics express [Biomed Opt Express] 2019 Jul 15; Vol. 10 (8), pp. 3974-3986. Date of Electronic Publication: 2019 Jul 15 (Print Publication: 2019).
DOI:	10.1364/BOE.10.003974
Abstrakt:	In this work, we compare the blood aggregation parameters measured in vitro by laser aggregometry and optical trapping techniques in blood samples with the parameters of blood rheology measured in vivo by digital capillaroscopy in the nail bed capillaries of patients suffering from the hypertension and coronary heart disease. We show that the alterations of the parameters measured in vivo and in vitro for patients with different stages of these diseases are interrelated. Good agreement between the results obtained with different techniques, and their applicability for the diagnostics of abnormalities of rheological properties of blood are demonstrated. Competing Interests: The authors declare that there are no conflicts of interest related to this article.
Databáze:	MEDLINE
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