Chronic kidney disease progression in patients with resistant hypertension subject to 2 therapeutic strategies: Intensification with loop diuretics vs aldosterone antagonists.

Autor:	Verdalles U; Departamento Nefrología, Hospital General Universitario Gregorio Marañón, Madrid, España. Electronic address: ursulaverdalles@yahoo.es., Goicoechea M; Departamento Nefrología, Hospital General Universitario Gregorio Marañón, Madrid, España., García de Vinuesa S; Departamento Nefrología, Hospital General Universitario Gregorio Marañón, Madrid, España., Torres E; Departamento Nefrología, Hospital General Universitario Gregorio Marañón, Madrid, España., Hernández A; Departamento Nefrología, Hospital General Universitario Gregorio Marañón, Madrid, España., Verde E; Departamento Nefrología, Hospital General Universitario Gregorio Marañón, Madrid, España., Pérez de José A; Departamento Nefrología, Hospital General Universitario Gregorio Marañón, Madrid, España., Luño J; Departamento Nefrología, Hospital General Universitario Gregorio Marañón, Madrid, España.
Jazyk:	English; Spanish; Castilian
Zdroj:	Nefrologia [Nefrologia (Engl Ed)] 2020 Jan - Feb; Vol. 40 (1), pp. 65-73. Date of Electronic Publication: 2019 Aug 23.
DOI:	10.1016/j.nefro.2019.04.012
Abstrakt:	Introduction: Actualy, there are few data about glomerular filtration rate (eGFR) drop in patients with resistant hypertension and how diferent therapies can modify chronic kidney disease progression (CKD). Objective: To evaluate CKD progression in patients with resistant hypertension undergoing 2diferent therapies: treatment with spironolactone or furosemide. Methods: We included 30 patients (21M, 9W) with a mean age of 66.3±9.1 years, eGFR 55.8±16.5ml/min/1.73 m 2 , SBP 162.8±8.2 and DBP 90.2±6.2mmHg: 15 patients received spironolactone and 15 furosemide and we followed up them a median of 32 months (28-41). Results: The mean annual eGFR decrease was -2.8±5.4ml/min/1.73 m 2 . In spironolactone group was -2.1±4.8ml/min/1.73 m 2 and in furosemide group was -3.2±5.6ml/min/1.73 m 2 , P<0.01. In patients received spironolactone, SBP decreased 23±9mmHg and in furosemide group decreased 16±3mmHg, P<.01. DBP decreased 10±8mmHg and 6±2mmHg, respectively (P<.01). Treatment with spironolactone reduced albuminuria from a serum albumin/creatine ratio of 210 (121-385) mg/g to 65 (45-120) mg/g at the end of follow-up, P<.01. There were no significant changes in the albumin/creatinine ratio in the furosemide group. The slower drop in kidney function was associated with lower SBP (P=.04), higher GFR (P=.01), lower albuminuria (P=.01), not diabetes mellitus (P=.01) and treatment with spironolactone (P=.02). Treatment with spironolactone (OR 2.13, IC 1.89-2.29) and lower albuminuria (OR 0.98, CI 0.97-0.99) maintain their independent predictive power in a multivariate model. Conclusion: Treatment with spironolactone is more effective reducing BP and albuminuria in patients with resistant hypertension compared with furosemide and it is associated with a slower progression of CKD in the long term follow up. (Copyright © 2019 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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