Airway exposure to TiO 2 nanoparticles and quartz and effects on sperm counts and testosterone levels in male mice.

Autor: Lauvås AJ; Danish Nanosafety Centre, National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 Copenhagen Ø, Denmark; Section for Veterinary Reproduction and Obstetrics, Department of Veterinary Clinical Sciences, University of Copenhagen, Dyrlægevej 68, 1870 Frederiksberg C, Denmark; Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, 1014 Copenhagen K, Denmark. Electronic address: anna.j.lauvas@gmail.com., Skovmand A; Danish Nanosafety Centre, National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 Copenhagen Ø, Denmark; Section for Veterinary Reproduction and Obstetrics, Department of Veterinary Clinical Sciences, University of Copenhagen, Dyrlægevej 68, 1870 Frederiksberg C, Denmark. Electronic address: aes@nrcwe.dk., Poulsen MS; Danish Nanosafety Centre, National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 Copenhagen Ø, Denmark. Electronic address: mspoulsen@gmail.com., Kyjovska ZO; Danish Nanosafety Centre, National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 Copenhagen Ø, Denmark. Electronic address: zokyjovska@gmail.com., Roursgaard M; Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, 1014 Copenhagen K, Denmark. Electronic address: mwro@sund.ku.dk., Goericke-Pesch S; Section for Veterinary Reproduction and Obstetrics, Department of Veterinary Clinical Sciences, University of Copenhagen, Dyrlægevej 68, 1870 Frederiksberg C, Denmark; Reproductive Unit of the Clinics - Clinic for Small Animals, University of Veterinary Medicine, Bünteweg 15, 30559 Hannover, Germany. Electronic address: sandra.goericke-pesch@tiho-hannover.de., Vogel U; Danish Nanosafety Centre, National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 Copenhagen Ø, Denmark; Department of Health Technology, DTU-Health, Technical University of Denmark, Ørsteds Plads, 2800 Lyngby, Denmark. Electronic address: ubv@arbejdsmiljoforskning.dk., Hougaard KS; Danish Nanosafety Centre, National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 Copenhagen Ø, Denmark; Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, 1014 Copenhagen K, Denmark. Electronic address: ksh@nrcwe.dk.
Jazyk: angličtina
Zdroj: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2019 Dec; Vol. 90, pp. 134-140. Date of Electronic Publication: 2019 Aug 23.
DOI: 10.1016/j.reprotox.2019.07.023
Abstrakt: Several types of engineered nanoparticles (ENP) have been shown to adversely affect male reproduction in rodent studies, but the airway route of exposure has been little investigated. This precludes adequate risk assessment of ENP exposure in occupational settings. Titanium dioxide nanoparticles (TiO 2 NP) have been shown to affect total sperm count in adult male mice after intravenous and oral administration. This study aimed to investigate whether also airway exposure would affect sperm counts in male mice. Mature C57BL/6J mice were intratracheally instilled with 63 μg of rutile nanosized TiO 2 , once weekly for seven weeks. Respirable α-quartz (SRM1878a) was included at a similar dose level as a positive control for pulmonary inflammation. BALF cell composition showed neutrophil granulocyte influx as indication of pulmonary inflammation in animals exposed to TiO 2 NP and α-quartz, but none of the particle exposures affected weight of testes or the epididymis, sperm counts or plasma testosterone when assessed at termination of the study.
(Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: