The presence of Aspergillus fumigatus is associated with worse respiratory quality of life in cystic fibrosis.

Autor: Hong G; Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA. Electronic address: gina.hong@pennmedicine.upenn.edu., Alby K; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA., Ng SCW; Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA., Fleck V; Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA., Kubrak C; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Rubenstein RC; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Dorgan DJ; Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA., Kawut SM; Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hadjiliadis D; Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
Jazyk: angličtina
Zdroj: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2020 Jan; Vol. 19 (1), pp. 125-130. Date of Electronic Publication: 2019 Aug 21.
DOI: 10.1016/j.jcf.2019.08.008
Abstrakt: Background: The clinical effects of Aspergillus fumigatus in the cystic fibrosis (CF) airway, with the exception of allergic bronchopulmonary aspergillosis, is unclear.
Methods: CF adolescents and adults (age 14 years and older) underwent bacterial and semi-selective fungal culture testing to determine the prevalence of fungi in the CF respiratory tract and the independent association between the presence of Aspergillus fumigatus and clinical characteristics.
Results: Aspergillus fumigatus (10.3%) and Candida species (57.8%) were the most common filamentous fungi and yeast seen respectively in the sputa of 206 individuals with CF. Inhaled corticosteroid (ICS) use was more common in Aspergillus fumigatus-positive than Aspergillus fumigatusnegative (100% versus 75.8%, p = .01). Aspergillus fumigatus was significantly associated with lower respiratory domain score (β -8.74, 95% CI -16.6, -0.88, p = .03), representing worse respiratory-related quality of life, accounting for demographics, disease characteristics, and the presence of a pulmonary exacerbation.
Conclusion: The presence of Aspergillus fumigatus in CF sputum was associated with worse respiratory quality of life in CF in a crosssectional, single center study. Longitudinal analysis examining the clinical implications of Aspergillus fumigatus on respiratory health over time is needed.
(Copyright © 2019 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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