Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia.

Autor: Zasada M; Department of Pediatrics, Jagiellonian University Medical College, Cracow, Poland., Suski M; Chair of Pharmacology, Jagiellonian University Medical College, Cracow, Poland., Bokiniec R; Neonatal and Intensive Care Department, Medical University of Warsaw, Warsaw, Poland., Szwarc-Duma M; Neonatal and Intensive Care Department, Medical University of Warsaw, Warsaw, Poland., Borszewska-Kornacka MK; Neonatal and Intensive Care Department, Medical University of Warsaw, Warsaw, Poland., Madej J; Chair of Pharmacology, Jagiellonian University Medical College, Cracow, Poland., Bujak-Giżycka B; Chair of Pharmacology, Jagiellonian University Medical College, Cracow, Poland., Madetko-Talowska A; Department of Medical Genetics, Jagiellonian University Medical College, Cracow, Poland., Revhaug C; Department of Pediatric Research, Oslo University Hospital, Oslo, Norway.; University of Oslo, Oslo, Norway., Baumbusch LO; Department of Pediatric Research, Oslo University Hospital, Oslo, Norway., Saugstad OD; Department of Pediatric Research, Oslo University Hospital, Oslo, Norway. Ola.D.Saugstad@rr-research.no.; University of Oslo, Oslo, Norway. Ola.D.Saugstad@rr-research.no., Pietrzyk JJ; Department of Pediatrics, Jagiellonian University Medical College, Cracow, Poland., Kwinta P; Department of Pediatrics, Jagiellonian University Medical College, Cracow, Poland.
Jazyk: angličtina
Zdroj: Italian journal of pediatrics [Ital J Pediatr] 2019 Aug 24; Vol. 45 (1), pp. 112. Date of Electronic Publication: 2019 Aug 24.
DOI: 10.1186/s13052-019-0676-0
Abstrakt: Background: In this study, we aimed to analyze differences in plasma protein abundances between infants with and without bronchopulmonary dysplasia (BPD), to add new insights into a better understanding of the pathogenesis of this disease.
Methods: Cord and peripheral blood of neonates (≤ 30 weeks gestational age) was drawn at birth and at the 36th postmenstrual week (36 PMA), respectively. Blood samples were retrospectively subdivided into BPD(+) and BPD(-) groups, according to the development of BPD.
Results: Children with BPD were characterized by decreased afamin, gelsolin and carboxypeptidase N subunit 2 levels in cord blood, and decreased galectin-3 binding protein and hemoglobin subunit gamma-1 levels, as well as an increased serotransferrin abundance in plasma at the 36 PMA.
Conclusions: BPD development is associated with the plasma proteome changes in preterm infants, adding further evidence for the possible involvement of disturbances in vitamin E availability and impaired immunological processes in the progression of prematurity pulmonary complications. Moreover, it also points to the differences in proteins related to infection resistance and maintaining an adequate level of hematocrit in infants diagnosed with BPD.
Databáze: MEDLINE
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