| Autor: |
Feitsma KG; Department of Analytical Chemistry and Toxicology, Groningen, The Netherlands., Postma DS, Koëter GH, Nossent GD, Brenth BF, de Zeeuw RA |
| Jazyk: |
angličtina |
| Zdroj: |
British journal of clinical pharmacology [Br J Clin Pharmacol] 1988 Jun; Vol. 25 (6), pp. 683-7. |
| DOI: |
10.1111/j.1365-2125.1988.tb05253.x |
| Abstrakt: |
1. Racemic oxyphenonium bromide, its enantiomers and placebo were inhaled by eight adult patients with chronic airflow obstruction, in a four-way double-blind cross-over study. 2. Forced expiratory volume in one second (FEV1) and slow inspiratory vital capacity (VC) were measured during the first 6 h after inhalation. 3. (+)-Oxyphenonium was found to be the active enantiomer (eutomer), providing better bronchodilation than (+/-)-oxyphenonium. 4. The distomer, (-)-oxyphenonium, showed only a slight effect on FEV1 and VC as compared with placebo. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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