| Autor: |
Perdikouri EIA; Department of Medical Oncology, Aristotle University of Thessaloniki School of Medicine, 54124 Thessaloniki and General Hospital of Volos, 38222 Volos, Greece., Arvaniti K; Intensive Care Unit, Infection Control Unit, Antibiotic Stewardship Committee, Papageorgiou University affiliated Hospital, 56403 Thessaloniki, Greece. arvanitik@hotmail.com., Lathyris D; Intensive Care Unit, G. Gennimatas Hospital, 54635 Thessaloniki, Greece., Apostolidou Kiouti F; Department of Hygiene and Biostatistics, Aristotle University of Thessaloniki School of Medicine, 54124 Thessaloniki, Greece., Siskou E; Microbiology and Biochemistry Department, Papageorgiou University affiliated Hospital, 56403 Thessaloniki, Greece., Haidich AB; Department of Hygiene and Biostatistics, Aristotle University of Thessaloniki School of Medicine, 54124 Thessaloniki, Greece., Papandreou C; Department of Medical Oncology, Aristotle University of Thessaloniki School of Medicine, 54124 Thessaloniki, Greece. |
| Abstrakt: |
Bacterial infections are frequent complications in cancer patients. Among them, those caused by multidrug-resistant (MDR) bacteria increase morbidity and mortality mainly because of limited therapeutic options. Current knowledge regarding MDR infections in patients with solid tumors is limited. We assessed the epidemiology and risk factors of increased mortality in these patients. In this retrospective five-year single cohort observational study, we included all oncological patients with MDR infections. Cancer-related parameters, comorbidities, prior use of antibiotics, previous surgical interventions and hospitalization, as well as the use of invasive procedures were investigated as potential risk factors causing adverse outcomes. Seventy-three patients with MDR infection were included: 37% with carbapenem-resistant Klebsiella pneumoniae , 24% with oxacillin-resistant Staphylococcus aureus (MRSA) and 21% with carbapenem-resistant Acinetobacter baumanni . Previous colonization with MDR bacteria was detected in 14% patients, while 20% of the patients presented MDR colonization or infection at ward admission. Mortality during the infection episode was 32%. Duration of hospitalization and CRP were statistically significant risk factors of mortality, whereas administration of guided antibiotics was a protective factor. Knowledge of local epidemiology of MDR bacteria can help physicians promptly identify cancer patients at risk of MDR infections and initiate timely effective empirical antibiotic treatment that can eventually improve the overall therapeutic management. |
