| Autor: |
Pike LC; King's College London and Guy's and St Thomas' PET Centre, School of Biomedical Engineering and Imaging Sciences, King's College London, King's Health Partners, London, UK., Thomas CM; King's College London and Guy's and St Thomas' PET Centre, School of Biomedical Engineering and Imaging Sciences, King's College London, King's Health Partners, London, UK.; Radiotherapy Physics, Guy's & St Thomas' NHS Foundation Trust, London, UK., Guerrero-Urbano T; Clinical Oncology, Guy's & St Thomas' NHS Foundation Trust, London, UK., Michaelidou A; Clinical Oncology, Guy's & St Thomas' NHS Foundation Trust, London, UK., Greener T; Radiotherapy Physics, Guy's & St Thomas' NHS Foundation Trust, London, UK., Miles E; National Radiotherapy Trials QA Group, Mount Vernon Hospital, Northwood, UK., Eaton D; Radiotherapy Physics, Guy's & St Thomas' NHS Foundation Trust, London, UK.; National Radiotherapy Trials QA Group, Mount Vernon Hospital, Northwood, UK., Barrington SF; King's College London and Guy's and St Thomas' PET Centre, School of Biomedical Engineering and Imaging Sciences, King's College London, King's Health Partners, London, UK. |
| Abstrakt: |
The aim of this article is to propose meaningful guidance covering the practical and technical issues involved when planning or conducting clinical trials involving positron emission tomography (PET)-guided radiotherapy. The complexity of imaging requirements will depend on the study aims, design and PET methods used. Where PET is used to adapt radiotherapy, a high level of accuracy and reproducibility is required to ensure effective and safe treatment delivery. The guidance in this document is intended to assist researchers designing clinical trials involving PET-guided radiotherapy to provide sufficient information about the appropriate methods to complete PET-CT imaging to a consistent standard at participating centres. The guidance is divided into six categories: application of PET in radiotherapy, resource requirements, quality assurance, imaging protocol design, data management and image processing. Each section provides an overview of the recent literature to support the specific recommendations. This guidance builds on previous recommendations from the National Cancer Research Institute PET Research Network and has been produced in collaboration with the National Radiotherapy Trials Quality Assurance Group. |
