Efficacy of chitosan derivative films versus hydrocolloid dressing on superficial wounds.

Autor: Halim AS; Reconstructive Sciences Unit, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Malaysia., Nor FM; Plastic and Reconstructive Surgery Unit, Department of Surgery, Hospital Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia., Mat Saad AZ; Reconstructive Sciences Unit, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Malaysia., Mohd Nasir NA; Reconstructive Sciences Unit, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Malaysia., Norsa'adah B; Biostatistics & Research Methodology Unit, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia., Ujang Z; SiRIM Industrial Research, SIRIM Bread, Shah Alam, Selangor, Malaysia.
Jazyk: angličtina
Zdroj: Journal of Taibah University Medical Sciences [J Taibah Univ Med Sci] 2018 Nov 17; Vol. 13 (6), pp. 512-520. Date of Electronic Publication: 2018 Nov 17 (Print Publication: 2018).
DOI: 10.1016/j.jtumed.2018.10.004
Abstrakt: Objectives: Chitosan, the N-deacetylated derivative of chitin, has useful biological properties that promote haemostasis, analgesia, wound healing, and scar reduction; chitosan is bacteriostatic, biocompatible, and biodegradable. This study determined the efficacy of chitosan derivative film as a superficial wound dressing.
Methods: This multicentre randomised controlled trial included 244 patients, of whom 86 were treated with chitosan derivative film and 84 with hydrocolloid. The percentage of epithelisation, as well as patient comfort, clinical signs, and patient convenience in application and removal of the dressings were assessed.
Results: The primary outcome of this study was the percentage of epithelisation. Except for race ( p  = 0.04), there were no significant differences between groups in sex, age, antibiotic usage, or initial wound size ( p  > 0.05). There was no significant difference in the mean epithelisation percentage between groups ( p  = 0.29). Patients using chitosan derivative film experienced more pain during removal of dressing than those in the hydrocolloid group ( p  = 0.007). The chitosan derivative film group showed less exudate ( p  = 0.036) and less odour ( p  = 0.024) than the control group. Furthermore, there were no significant differences between groups in terms of adherence, ease of removal, wound drainage, erythema, itchiness, pain, and tenderness. No oedema or localised warmth was observed during the study.
Conclusion: This study concluded that chitosan derivative film is equivalent to hydrocolloid dressing and can be an option in the management of superficial and abrasion wounds.
Clinical Trial No: NMRR-11-948-10565.
Databáze: MEDLINE
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