Galanin administration into the prelimbic cortex impairs consolidation and expression of contextual fear conditioning.

Autor: Hooversmith JM; Neuroscience Division of the Biomedical and Health Sciences Institute, University of Georgia, 310 E Campus Road, Athens, GA, 30602, USA., Bhatti DL; Psychology Department, University of Georgia, 125 Baldwin Street, Athens, GA, 30602, USA; Dionnet L. Bhatti is now in the Laboratory of Molecular and Cellular Neuroscience at The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA., Holmes PV; Neuroscience Division of the Biomedical and Health Sciences Institute, University of Georgia, 310 E Campus Road, Athens, GA, 30602, USA; Psychology Department, University of Georgia, 125 Baldwin Street, Athens, GA, 30602, USA. Electronic address: pvholmes@uga.edu.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2019 Dec 16; Vol. 375, pp. 112160. Date of Electronic Publication: 2019 Aug 18.
DOI: 10.1016/j.bbr.2019.112160
Abstrakt: The neuropeptide galanin is a potential therapeutic target for treating stress-related disorders, such as post-traumatic stress disorder (PTSD); however, its effects on contextual fear conditioning (CFC), an accepted animal model of PTSD, are not well understood. Dysregulation of the medial prefrontal cortex (mPFC) is implicated in PTSD. We investigated the effects of galanin (1 ug) administrated bilaterally into the prelimbic cortex, a division of the mPFC, on the consolidation, expression, and extinction of CFC of male Sprague-Dawley rats. Galanin administration significantly reduced consolidation and expression of CFC, but had no effect on retention or retrieval of extinction learning. These data further implicate galanin as a potential therapeutic target for treating stress-related disorders, particularly those characterized by aberrant emotional memory.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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