Chemical Modification of Alginate for Controlled Oral Drug Delivery.

Autor:	Banks SR; Department of Chemistry , Wake Forest University , 455 Vine Street , Winston-Salem , North Carolina 27101 , United States., Enck K; Wake Forest Institute for Regenerative Medicine , Wake Forest School of Medicine , Medical Center Boulevard Winston-Salem , North Carolina 27101 , United States.; Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences , Wake Forest School of Medicine , Medical Center Boulevard , Winston-Salem , North Carolina 27157 , United States., Wright M; Department of Chemistry , Wake Forest University , 455 Vine Street , Winston-Salem , North Carolina 27101 , United States., Opara EC; Wake Forest Institute for Regenerative Medicine , Wake Forest School of Medicine , Medical Center Boulevard Winston-Salem , North Carolina 27101 , United States.; Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences , Wake Forest School of Medicine , Medical Center Boulevard , Winston-Salem , North Carolina 27157 , United States., Welker ME; Department of Chemistry , Wake Forest University , 455 Vine Street , Winston-Salem , North Carolina 27101 , United States.
Jazyk:	angličtina
Zdroj:	Journal of agricultural and food chemistry [J Agric Food Chem] 2019 Sep 18; Vol. 67 (37), pp. 10481-10488. Date of Electronic Publication: 2019 Sep 04.
DOI:	10.1021/acs.jafc.9b01911
Abstrakt:	Here, we report two methods that chemically modify alginate to achieve neutral-basic pH sensitivity of the resultant hydrogel. The first method involves direct amide bond formation between alginate and 4-(2-aminoethyl)benzoic acid. The second method that arose out of the desire to achieve better control of the degradation rate of the alginate hydrogel involves reductive amination of oxidized alginate. The products of both methods result in a hydrogel vehicle for targeted delivery of encapsulated payload under physiological conditions in the gastrointestinal tract. Two-dimensional diffusion-ordered spectroscopy and internal and coaxial external nuclear magnetic resonance standards were used to establish chemical bonding and percent incorporation of the modifying groups into the alginate polymer. The hydrogel made with alginate modified by each method was found to be completely stable under acidic pH conditions while disintegrating within minutes to hours in neutral-basic pH conditions. We found that, while alginate oxidation did not affect the β-d-mannuronate/α-l-guluronate ratio of alginate, the rate of disintegration of the hydrogel made with oxidized alginate was dependent upon the degree of oxidation.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu