Elevated copeptin, arterial stiffness, and elevated albumin excretion in adolescents with type 1 diabetes.

Autor:	Wiromrat P; Section of Endocrinology, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado., Bjornstad P; Section of Endocrinology, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado.; Section of Nephrology, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado., Vinovskis C; Section of Endocrinology, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado., Chung LT; Section of Endocrinology, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado., Roncal C; Section of Nephrology, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado., Pyle L; Section of Endocrinology, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado.; Barbara Davis Center for Childhood Diabetes, University of Colorado Denver School of Medicine, Aurora, Colorado., Lanaspa MA; Section of Nephrology, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado., Johnson RJ; Section of Nephrology, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado., Cherney DZ; Department of Biostatistics and Informatics, University of Colorado Denver School of Public Health, Aurora, Colorado., Reznick-Lipina TK; Department of Nephrology, University of Toronto School of Medicine, Toronto, Ontario, Canada., Bishop F; Department of Nephrology, University of Toronto School of Medicine, Toronto, Ontario, Canada., Maahs DM; Section of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California.; Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, California., Wadwa RP; Department of Nephrology, University of Toronto School of Medicine, Toronto, Ontario, Canada.
Jazyk:	angličtina
Zdroj:	Pediatric diabetes [Pediatr Diabetes] 2019 Dec; Vol. 20 (8), pp. 1110-1117. Date of Electronic Publication: 2019 Aug 29.
DOI:	10.1111/pedi.12909
Abstrakt:	Objective: We sought to evaluate copeptin concentrations in adolescents with and without type 1 diabetes (T1D) and examine the associations between copeptin and measures of arterial stiffness and kidney dysfunction. Research Design and Methods: This analysis included 169 adolescents with T1D (12-19 years of age, 59% girls, mean HbA1c 9.0 ± 1.5% and diabetes duration of 8.6 ± 2.9 years), in addition to 61 controls without T1D. Arterial stiffness including carotid-femoral pulse wave velocity (CF-PWV), carotid-radial PWV (CR-PWV), augmentation index normalized to heart rate of 75 bpm (AIx@HR75), and brachial artery distensibility (BAD). Serum copeptin, urinary albumin-to-creatinine ratio (UACR), and estimated glomerular filtration rate (eGFR) by serum creatinine and cystatin C were also assessed. Results: Compared to controls, adolescents with T1D had higher median (Q1-Q3) copeptin (7.5 [5.2-11.3] vs 6.4 [4.8-8.3] pmol/L, P = .01), mean ± SD eGFR (121 ± 23 vs 112 ± 16 mL/min/1.73m 2 , P = .002) and lower BAD (7.1 ± 1.3 vs 7.2 ± 1.2%, P = .02). Adolescents with T1D in the in high tertile copeptin group (>9.1 pmol/L) had higher AIx@HR75 (10.7 ± 1.2 vs 5 ± 1.2, P = .001), CR-PWV (5.30 ± 1.0 vs 5.18 ± 1.0 m/s, P = .04), and UACR (12 ± 1 vs 8 ± 1 mg/g, P = .025) compared to those in low tertile (<5.8 pmol/L) after adjusting for age, sex, and eGFR. Copeptin inversely associated with CF-PWV independent of age, sex, eGFR, SBP, and HbA1c in T1D adolescents. Conclusions: Our data demonstrate that elevated copeptin was associated with worse arterial stiffness in adolescents with T1D. These findings suggest that copeptin could improve CVD risk stratification in adolescents with T1D. (© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze:	MEDLINE
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