Bioinspired RGD-Engineered Bacteriophage Nanofiber Cues against Oxidative Stress.

Autor:	Chae SY; BIO-IT Foundry Technology Institute, Pusan National University , Busan 46241 , Republic of Korea.; Department of Nano Fusion Technology , Pusan National University , Busan 46241 , Republic of Korea., Shrestha KR; BIO-IT Foundry Technology Institute, Pusan National University , Busan 46241 , Republic of Korea.; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital , Yangsan 50612 , Republic of Korea., Jeong SN; BIO-IT Foundry Technology Institute, Pusan National University , Busan 46241 , Republic of Korea.; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital , Yangsan 50612 , Republic of Korea., Park G; BIO-IT Foundry Technology Institute, Pusan National University , Busan 46241 , Republic of Korea.; Department of Nano Fusion Technology , Pusan National University , Busan 46241 , Republic of Korea., Yoo SY; BIO-IT Foundry Technology Institute, Pusan National University , Busan 46241 , Republic of Korea.; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital , Yangsan 50612 , Republic of Korea.
Jazyk:	angličtina
Zdroj:	Biomacromolecules [Biomacromolecules] 2019 Oct 14; Vol. 20 (10), pp. 3658-3671. Date of Electronic Publication: 2019 Aug 30.
DOI:	10.1021/acs.biomac.9b00640
Abstrakt:	Instructive tissue engineering biomaterials provide a vascular niche and protect oxidative stress in injured tissue. In this study, we exploited bioinspired bacteriophage nanofibers, previously recognized by their biochemical and structural cues inducing angiogenesis, as an antioxidant tissue engineering material. We demonstrated that topological cues of Arg-Gly-Asp (RGD)-engineered bacteriophage nanofibers provide angiogenic niches and cytoprotective functions against cellular oxidative stress with increased expression of antioxidant enzymes heme oxygenase-1 (HO-1) and NAD(P)H-quinone oxidoreductase 1 (NQO1) via the extracellular-signal-regulated kinase (ERK)-nuclear factor erythroid 2-related factor2 (Nrf2)-mediated signaling pathway, where a high density of RGD cues on the phage body support efficient interaction of cells with phage cues. These bioinspired RGD-engineered bacteriophage nanofibers can serve as a novel therapeutic platform for curing ischemic diseases.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu