Comparison of IVIg 5% Versus 10% in hematological patients with a secondary immunodeficiency disorder.

Autor:	Van Ham J; Department of Hematology, University Hospital Leuven , Leuven, Belgium., Janssens A; Department of Hematology, University Hospital Leuven , Leuven, Belgium., Raddoux J; Department of Hematology, University Hospital Leuven , Leuven, Belgium., Raets E; Department of Hematology, University Hospital Leuven , Leuven, Belgium., Delforge M; Department of Hematology, University Hospital Leuven , Leuven, Belgium.
Jazyk:	angličtina
Zdroj:	Acta clinica Belgica [Acta Clin Belg] 2021 Feb; Vol. 76 (1), pp. 49-52. Date of Electronic Publication: 2019 Aug 17.
DOI:	10.1080/17843286.2019.1655860
Abstrakt:	Objective : The aim of this study was to evaluate the administration of intravenous immunoglobulin (IVIg) solutions (5% vs. 10%) in hematological patients suffering from a secondary immunodeficiency (SID) to optimize infusion duration and hospitalization time. Design : A monocentric, observational study in 30 patients with secondary hypogammaglobulinemia due to a lymphoproliferative disorder currently under IVIg 5% treatment. A sequential approach was followed with observations during IVIg 5% and 10% administration 3 to 4 weeks later. Infusion time, time spent at the day clinic, IVIg-related adverse events and number of actions taken by the nursing staff were evaluated and compared between the 5% and 10% infusions. Questionnaires for patients and nursing staff were obtained after IVIg 10% to assess their satisfaction with the change of infusion. Results : Average infusion time was reduced from 4.92 h to 2.29 h (p < 0.0001). Time spent at the day clinic was 5.87 h for the 5% IVIg administration and 4.56 h for the 10% (p = 0.0005). IVIg-related adverse events rose from 0 to 0.43 per patient. No serious adverse events were reported. Nursing actions per patient decreased from 1.03 to 0.67. Patient and nursing satisfaction were respectively 83% and 96% in favor of IVIg 10%. Conclusion : A 10% IVIg solution can significantly reduce infusion time and overall duration of the day clinic visit. Care must be taken to minimize new infusion-related adverse events. Switching to a 10% IVIg administration increases patient and nursing satisfaction but also requires additional workflow changes to further shorten the day clinic visit.
Databáze:	MEDLINE
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