Anti-amyloid activities of three different types of water-soluble fullerene derivatives.

Autor: Bobylev AG; Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Institutskaya St. 3, Pushchino, Moscow Region, 142290, Russia., Kraevaya OA; Skolkovo Institute of Science and Technology, Nobel St. 3, Moscow, 143026, Russia; Institute for Problems of Chemical Physics of the Russian Academy of Sciences, Semenov Prospect 1, Chernogolovka, 141432, Russia., Bobyleva LG; Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Institutskaya St. 3, Pushchino, Moscow Region, 142290, Russia., Khakina EA; Institute for Problems of Chemical Physics of the Russian Academy of Sciences, Semenov Prospect 1, Chernogolovka, 141432, Russia., Fadeev RS; Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Institutskaya St. 3, Pushchino, Moscow Region, 142290, Russia., Zhilenkov AV; Institute for Problems of Chemical Physics of the Russian Academy of Sciences, Semenov Prospect 1, Chernogolovka, 141432, Russia., Mishchenko DV; Institute for Problems of Chemical Physics of the Russian Academy of Sciences, Semenov Prospect 1, Chernogolovka, 141432, Russia., Penkov NV; Institute of Cell Biophysics of the Russian Academy of Sciences, Federal Research Center 'Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences', Institutskaya St., 3, Pushchino, Moscow Region, 142290, Russia., Teplov IY; Institute of Cell Biophysics of the Russian Academy of Sciences, Federal Research Center 'Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences', Institutskaya St., 3, Pushchino, Moscow Region, 142290, Russia., Yakupova EI; Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Institutskaya St. 3, Pushchino, Moscow Region, 142290, Russia., Vikhlyantsev IM; Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Institutskaya St. 3, Pushchino, Moscow Region, 142290, Russia., Troshin PA; Skolkovo Institute of Science and Technology, Nobel St. 3, Moscow, 143026, Russia; Institute for Problems of Chemical Physics of the Russian Academy of Sciences, Semenov Prospect 1, Chernogolovka, 141432, Russia. Electronic address: troshin2003@inbox.ru.
Jazyk: angličtina
Zdroj: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2019 Nov 01; Vol. 183, pp. 110426. Date of Electronic Publication: 2019 Aug 09.
DOI: 10.1016/j.colsurfb.2019.110426
Abstrakt: Anti-amyloid activity, aggregation behaviour, cytotoxicity and acute toxicity were investigated for three water-soluble fullerene derivatives with different types of solubilizing addends. All investigated compounds showed a strong anti-amyloid effect in vitrocaused by interaction of the water-soluble fullerene derivatives with the Ab(1-42)-peptide and followed by destruction of the amyloid fibrils. Notably, all of the studied fullerene derivatives showed very low cytotoxicity and low acute toxicity in mice (most promising compound 3 was more than four times less toxic than aspirin). Strong anti-amyloid effect of the fullerene derivatives together with low toxicity reveals high potential of these compounds as drug candidates for treatment of neurodegenerative diseases.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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