In vitro effects of progesterone and the synthetic progestin medroxyprogesterone acetate on vascular remodeling.

Autor: Cutini PH; Instituto de Ciencias Biológicas y Biomédicas del Sur (INBIOSUR), Universidad Nacional del Sur (UNS), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Departamento de Biología, Bioquímica y Farmacia, UNS, San Juan 670, B8000ICN, Bahía Blanca, Argentina. Electronic address: pcutini@uns.edu.ar., Massheimer VL; Instituto de Ciencias Biológicas y Biomédicas del Sur (INBIOSUR), Universidad Nacional del Sur (UNS), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Departamento de Biología, Bioquímica y Farmacia, UNS, San Juan 670, B8000ICN, Bahía Blanca, Argentina. Electronic address: massheim@uns.edu.ar.
Jazyk: angličtina
Zdroj: Molecular and cellular endocrinology [Mol Cell Endocrinol] 2019 Dec 01; Vol. 498, pp. 110543. Date of Electronic Publication: 2019 Aug 14.
DOI: 10.1016/j.mce.2019.110543
Abstrakt: In this work we tested the hypothesis whether progesterone (Pg) or the synthetic progestin medroxyprogesterone acetate (MPA) could be involved in the regulation of events involved in vascular remodeling. Results revealed an enhancement in the capillary-like tubes formation induced by both progestogens. Unlike MPA, Pg acts through VEGF, nitric oxide, PI3K and ERK1/2 signaling pathways. However, the MPA effect depends on platelet activation. Under stress conditions, the proangiogenic action of Pg and MPA was sustained. The progestogens exhibit the ability to prevent vascular smooth muscle cells (VSMC) osteogenic transdifferentiation. Besides this antiosteogenic action, on bone cells the progestogens induced osteoblast maturation and mineralization. The mechanism of action of both steroids on vascular and bone cells involves the participation of progesterone receptor. The data presented in this work provide evidence that the progestogens reduce osteogenic-like transdifferentiation of VSMC and promote angiogenesis with a slight different mechanism of action elicited by each steroid.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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