Fractional Erbium-YAG Laser and Platelet-Rich Plasma as Single or Combined Treatment for Atrophic Acne Scars: A Randomized Clinical Trial.

Autor: El-Taieb MA; Dermatology, Venereology and Andrology, Aswan Faculty of Medicine, Aswan University, Aswan, Egypt. moustafa.eltaib@aswu.edu.eg., Ibrahim HM; Dermatology, Venereology and Andrology, Qena Faculty of Medicine, South Valley University, Qena, Egypt., Hegazy EM; Dermatology, Venereology and Andrology, Qena Faculty of Medicine, South Valley University, Qena, Egypt., Ibrahim AK; Community Medicine, Asuit University, Asyut, Egypt., Gamal AM; Dermatology, Venereology and Andrology, Students' Hospital, South Valley University, Qena, Egypt., Nada EA; Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt.
Jazyk: angličtina
Zdroj: Dermatology and therapy [Dermatol Ther (Heidelb)] 2019 Dec; Vol. 9 (4), pp. 707-717. Date of Electronic Publication: 2019 Aug 16.
DOI: 10.1007/s13555-019-00318-1
Abstrakt: Introduction: Acne scarring is a common undesirable complication of acne vulgaris. Fractional erbium-yttrium aluminum garnet (YAG) 2940 nm laser and platelet-rich plasma have been used in treating acne scars with variable outcomes. The objective of this study is to assess the efficacy of fractional erbium-YAG 2940 nm laser and platelet-rich plasma as a single line of treatment in comparison with combined treatment in atrophic postacne scars.
Methods: Seventy-five patients were included in this trial and randomized into three equal groups (25 each). Group A was subjected to six sessions of erbium-YAG laser for 6 months, group B was treated with 12 sessions of platelet-rich plasma over the same period, and group C was subjected to six sessions of erbium-YAG laser plus 12 sessions of platelet-rich plasma over the same period. Each subject was evaluated by acne scar grading, photography, and subjective evaluation.
Results: Both treatment modalities showed improvement of acne scars, but the improvement with combined treatment was better than that with erbium-YAG laser or platelet-rich plasma alone regarding scar grade improvement (P = 0.007 and 0.001), clinical improvement (P = 0.001 and 0.001), and patient satisfaction (P = 0.005 and 0.001), respectively.
Conclusions: The combination of platelet-rich plasma plus erbium-YAG laser is superior to either treatment alone for acne scars, with trivial side effects for all treatment modalities.
Trial Registration: ClinicalTrials.gov identifier; NCT03933033.
Databáze: MEDLINE
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