Prognostic value of microvessel density in stage II and III colon cancer patients: a retrospective cohort study.

Autor: den Uil SH; Department of Surgery, Spaarne Gasthuis, Boerhaavelaan 22, Haarlem, 2035 RC, The Netherlands.; Department of Pathology, Amsterdam University Medical Centre, Vrije Universiteit Amsterdam, de Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands., van den Broek E; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.; Department of Pathology, Amsterdam University Medical Centre, Vrije Universiteit Amsterdam, de Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands., Coupé VMH; Department of Epidemiology and Biostatistics, VU University Medical Center, de Boelelaan 1089a, Amsterdam, 1081 HV, The Netherlands., Vellinga TT; Department of Surgical Oncology, UMC Utrecht Cancer Center, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, The Netherlands., Delis-van Diemen PM; Department of Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands., Bril H; Department of Pathology, Spaarne Gasthuis, Boerhaavelaan 22, Haarlem, 2035 RC, The Netherlands., Belt EJT; Department of Surgery, Albert Schweitzer Ziekenhuis, Dordrecht, 3300 AK, The Netherlands., Kranenburg O; Department of Surgical Oncology, UMC Utrecht Cancer Center, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, The Netherlands., Stockmann HBAC; Department of Surgery, Spaarne Gasthuis, Boerhaavelaan 22, Haarlem, 2035 RC, The Netherlands., Belien JAM; Department of Pathology, Amsterdam University Medical Centre, Vrije Universiteit Amsterdam, de Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands., Meijer GA; Department of Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands., Fijneman RJA; Department of Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands. r.fijneman@nki.nl.
Jazyk: angličtina
Zdroj: BMC gastroenterology [BMC Gastroenterol] 2019 Aug 16; Vol. 19 (1), pp. 146. Date of Electronic Publication: 2019 Aug 16.
DOI: 10.1186/s12876-019-1063-4
Abstrakt: Background: Microvessel density (MVD), as a derived marker for angiogenesis, has been associated with poor outcome in several types of cancer. This study aimed to evaluate the prognostic value of MVD in stage II and III colon cancer and its relation to tumour-stroma-percentage (TSP) and expression of HIF1A and VEGFA.
Methods: Formalin-fixed paraffin-embedded (FFPE) colon cancer tissues were collected from 53 stage II and 54 (5-fluorouracil-treated) stage III patients. MVD was scored by digital morphometric analysis of CD31-stained whole tumour sections. TSP was scored using haematoxylin-eosin stained slides. Protein expression of HIF1A and VEGFA was determined by immunohistochemical evaluation of tissue microarrays.
Results: Median MVD was higher in stage III compared to stage II colon cancers (11.1% versus 5.6% CD31-positive tissue area, p < 0.001). High MVD in stage II patients tended to be associated with poor disease free survival (DFS) in univariate analysis (p = 0.056). In contrast, high MVD in 5FU-treated stage III patients was associated with better DFS (p = 0.006). Prognostic value for MVD was observed in multivariate analyses for both cancer stages.
Conclusions: MVD is an independent prognostic factor associated with poor DFS in stage II colon cancer patients, and with better DFS in stage III colon cancer patients treated with adjuvant chemotherapy.
Databáze: MEDLINE
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