Early LV remodelling patterns in overweight and obesity: Feasibility of cardiac CT to detect early geometric left ventricular changes.

Autor: Walpot J; University of Ottawa Heart Institute, Division of Cardiology, Canada., Inácio JR; University of Ottawa, Department of Radiology, The Ottawa Hospital, Medical Imaging and The Ottawa Hospital Research Institute, Ottawa, ON, Canada., Massalha S; University of Ottawa Heart Institute, Division of Cardiology, Canada., El Mais H; University of Ottawa Heart Institute, Division of Cardiology, Canada., Hossain A; University of Ottawa Heart Institute, Cardiovascular Research Methods Centre, Canada., Shiau J; University of Ottawa, Department of Medicine, Division of Endocrinology and Metabolism, LEAF Weight Management Clinic, Canada., Small GR; University of Ottawa Heart Institute, Division of Cardiology, Canada., Crean AM; University of Ottawa Heart Institute, Division of Cardiology, Canada., Yam Y; University of Ottawa Heart Institute, Division of Cardiology, Canada., Rybicki F; University of Ottawa, Department of Radiology, The Ottawa Hospital, Medical Imaging and The Ottawa Hospital Research Institute, Ottawa, ON, Canada., Chow BJW; University of Ottawa Heart Institute, Division of Cardiology, Canada; University of Ottawa, Department of Radiology, The Ottawa Hospital, Medical Imaging and The Ottawa Hospital Research Institute, Ottawa, ON, Canada. Electronic address: bchow@ottawaheart.ca.
Jazyk: angličtina
Zdroj: Obesity research & clinical practice [Obes Res Clin Pract] 2019 Sep - Oct; Vol. 13 (5), pp. 478-485. Date of Electronic Publication: 2019 Aug 12.
DOI: 10.1016/j.orcp.2019.07.002
Abstrakt: Background: Obesity is an in independent risk factor for cardiovascular disease.
Goal: To describe the early LV remodelling pattern in patients with overweight and obesity and structurally normal hearts.
Methods: Consecutive patients (n = 2374), with structurally normal hearts and BMI ≥ 18.5 kg/m 2 , undergoing prospective mid-diastolic ECG gated CTCA were selected. Left ventricular mass (LVM) and Left ventricular mid-diastolic volume (LVMDV) were measured. The concentricity index (LVM/LVMDV) were calculated. According to the definitions of the World Health Organization (WHO), the patients were divided into weight categories.
Results: The mean LVM ± Std. deviation in the subgroups according to WHO classification was 101.68 ± 28.99 g (normal weight), 115.79 ± 29.14 g (overweight), 123.8 ± 33.44 g (class I obesity), 125.85 ± 32.89 g (class II obesity) and 132.45 ± 37.85 g (class III obesity). (p < 0.001) The mean LVMDV progressed with increasing WHO weight category from 112.37 ± 36.46 in patients with normal BMI to 140.26 ± 43.78 in patients with class III obesity. (p < 0.001) The concentricity index was 0.935 ± 0.216 g/ml in patients with normal BMI, 0.979 ± 0.253 g/ml, 1.058 ± 0.635 g/ml, 0.996 ± 0.284 g/ml and 0.9768 ± 0.244 g/ml in patients with BMI categories 25-29.99, 30-34.99, 35-39.99 and ≥40 kg/m 2 , respectively.
Conclusions: Our study demonstrates a non-linear (inverse U-shape) relationship between increasing BMI class and concentricity index, reaching its maximum at a BMI of 30-34.99 kg/m 2 . Further increase in BMI results in LV dilation.
(Copyright © 2019 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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