| Autor: |
Marijt KA; Department of Medical Oncology, Leiden University Medical Center, Leiden, Netherlands., Van Der Burg SH; Department of Medical Oncology, Leiden University Medical Center, Leiden, Netherlands., van Hall T; Department of Medical Oncology, Leiden University Medical Center, Leiden, Netherlands. |
| Jazyk: |
angličtina |
| Zdroj: |
Oncoimmunology [Oncoimmunology] 2019 May 13; Vol. 8 (8), pp. 1599639. Date of Electronic Publication: 2019 May 13 (Print Publication: 2019). |
| DOI: |
10.1080/2162402X.2019.1599639 |
| Abstrakt: |
The intracellular peptide pump TAP feeds antigenic peptides for loading onto HLA class I molecules, and its down-modulation is a frequent immune evasion mechanism in human cancers. Two recent papers describe which 'hidden' antigens we might exploit to target these escaped cancer variants by CD8 T cells. These unTAPped peptides are now ready for clinical testing. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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