[Clinical and morphological characteristics of thyroid tumors in children of the Chelyabinsk Region].

Autor:	Kazachkov EL; South Ural State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia., Pasternak IA; South Ural State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia., Pasternak AE; Chelyabinsk Regional Forensic Medical Examination Bureau, Ministry of Health of the Chelyabinsk Region, Chelyabinsk, Russia.
Jazyk:	ruština
Zdroj:	Arkhiv patologii [Arkh Patol] 2019; Vol. 81 (4), pp. 53-58.
DOI:	10.17116/patol20198104153
Abstrakt:	Objective: To carry out a clinical and morphological analysis of thyroid cancer cases in the children of the Chelyabinsk Region. Subject and Methods: Thyroid tumor pathology was verified in 50 of the 196 patients aged 7-17 years, who had been operated on in 2000-2016. Clinical and morphological features, including immunohistochemical and ultrastructural characteristics of thyroid cancer, were studied. Results: Over the past 17 years, there has been a decline in the number of children with surgical thyroid diseases, including thyroid carcinomas. There is a predominance of papillary carcinoma (70%) that is characterized by more aggressive clinical and morphological signs than follicular and medullary thyroid carcinoma. The immunophenotype of follicular cell tumors in children is characterized by the expression of growth factors (TTF-1, EGFR-384) and malignancy markers (mesothelial cell, AMACR (P504S), S 100). Conclusion: The vector change (decrease) in the long-term unfavorable trend toward an increasing incidence of thyroid cancer in children of the Chelyabinsk Region is currently accompanied by the pathomorphism of thyroid carcinoma.
Databáze:	MEDLINE
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