[The study of fenspiride: goals and objectives for chemical and toxicological studies].

Autor:	Kalekin RA; Federal Center for Forensic Medical Expertise of the Ministry of Health of the Russian Federation, Moscow, Russia, 125284., Orlova AM; Federal Center for Forensic Medical Expertise of the Ministry of Health of the Russian Federation, Moscow, Russia, 125284., Savchuk SA; Federal Center for Forensic Medical Expertise of the Ministry of Health of the Russian Federation, Moscow, Russia, 125284., Barsegyan SS; Federal Center for Forensic Medical Expertise of the Ministry of Health of the Russian Federation, Moscow, Russia, 125284.
Jazyk:	ruština
Zdroj:	Sudebno-meditsinskaia ekspertiza [Sud Med Ekspert] 2019; Vol. 62 (4), pp. 37-41.
DOI:	10.17116/sudmed20196204137
Abstrakt:	The purpose of this work is to study fenspiride for the purposes and tasks of chemical and toxicological research. The technique of chemical-toxicological study of fenspiride in urine by preliminary and confirming methods is proposed. The authors proposed a method of thin - layer chromatography in the solvent system of acetone - 25% ammonia solution (9:1) in a preliminary study of fenspiride. The Rf value of fenspiride is 0.80±0.02. The degree of extraction when used as an extractant mixture of chloroform-propanol (9:1) is 28.1±1.4% The conditions for identification of fenspiride by gas chromatography-mass spectrometry (fenspiride retention time 11.1±0.1 minutes), followed by quantitative determination of the analyte, are proposed as a confirming method. The conditions for qualitative (retention time of fenspiride 8.1±0.1 minutes) and quantitative determination of fenspiride by high-performance liquid chromatography are proposed.
Databáze:	MEDLINE
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