In vivo evaluation of human patellar tendon microstructure and microcirculation with diffusion MRI.
Autor: | Wengler K; Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA., Fukuda T; Department of Radiology, Stony Brook University, Stony Brook, New York, USA., Tank D; Department of Radiology, Stony Brook University, Stony Brook, New York, USA., Komatsu DE; Department of Orthopaedics, Stony Brook University, Stony Brook, New York, USA., Paulus M; Department of Orthopaedics, Stony Brook University, Stony Brook, New York, USA., Huang M; Department of Radiology, Stony Brook University, Stony Brook, New York, USA., Gould ES; Department of Radiology, Stony Brook University, Stony Brook, New York, USA., Schweitzer ME; Department of Radiology, Stony Brook University, Stony Brook, New York, USA., He X; Department of Radiology, Stony Brook University, Stony Brook, New York, USA. |
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Jazyk: | angličtina |
Zdroj: | Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2020 Mar; Vol. 51 (3), pp. 780-790. Date of Electronic Publication: 2019 Aug 12. |
DOI: | 10.1002/jmri.26898 |
Abstrakt: | Background: Patellar tendon (PT) microstructure integrity and microcirculation status play a crucial role in the progression of tendinopathy and tendon repair. Purpose: To assess the feasibility and robustness of stimulated-echo based diffusion-weighted MRI with readout-segmented echo-planar imaging (ste-RS-EPI) for noninvasive assessment of microstructure and microcirculation of human PT. Study Type: Prospective. Subjects: Fifteen healthy volunteers. Field Strength/sequence: PT diffusion tensor imaging (DTI) and intravoxel incoherent motion (IVIM) were acquired with an ste-RS-EPI protocol on a 3T MRI scanner. Assessment: Subjects were positioned with their PT at the magic angle. DTI-derived parameters including axial diffusivity (AD), radial diffusivity (RD), mean diffusivity (MD), and fractional anisotropy (FA) were estimated with b-values of 0 and 800 s/mm 2 and 12 diffusion directions. IVIM-derived parameters, f Statistical Tests: Paired t-tests were used to evaluate differences in IVIM parameters between the central-third and outer-two thirds regions of the patellar tendon. Paired t-tests and within-subject coefficient of variation were used to assess the intra- and intersession reproducibility of PT DTI and IVIM parameters. Results: DTI parameters for healthy PT were 1.54 ± 0.09 × 10 -3 mm 2 /s, 1.01 ± 0.05 × 10 -3 mm 2 /s, 1.18 ± 0.06 × 10 -3 mm 2 /s, and 0.30 ± 0.04 for AD, RD, MD, and FA, respectively. Significantly higher (P < 0.05) IVIM parameters f Data Conclusion: Diffusion MRI of PT with an ste-RS-EPI protocol is clinically feasible. Both DTI- and IVIM-derived parameters of the PT demonstrated good test-retest reproducibility and interrater reliability. Level of Evidence: 2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2020;51:780-790. (© 2019 International Society for Magnetic Resonance in Medicine.) |
Databáze: | MEDLINE |
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