Myelin Water Fraction and Intra/Extracellular Water Geometric Mean T 2 Normative Atlases for the Cervical Spinal Cord from 3T MRI.

Autor: Liu H; Department of Physics & Astronomy, University of British Columbia, Vancouver, Canada.; International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, Canada., Ljungberg E; Department of Neuroimaging, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UK., Dvorak AV; Department of Physics & Astronomy, University of British Columbia, Vancouver, Canada.; International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, Canada., Lee LE; Department of Medicine, University of British Columbia, Vancouver, Canada., Yik JT; Department of Physics & Astronomy, University of British Columbia, Vancouver, Canada.; International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, Canada., MacMillan EL; Philips, Markham, Canada.; School of Mechatronic Systems Engineering, Simon Fraser University, Canada.; Department of Radiology, University of British Columbia, Vancouver, Canada., Barlow L; Philips, Markham, Canada., Li DKB; Department of Medicine, University of British Columbia, Vancouver, Canada.; Department of Radiology, University of British Columbia, Vancouver, Canada., Traboulsee A; Department of Medicine, University of British Columbia, Vancouver, Canada., Kolind SH; Department of Physics & Astronomy, University of British Columbia, Vancouver, Canada.; International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, Canada.; Department of Medicine, University of British Columbia, Vancouver, Canada.; Department of Radiology, University of British Columbia, Vancouver, Canada., Kramer JLK; International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, Canada.; School of Kinesiology, University of British Columbia, Vancouver, Canada., Laule C; Department of Physics & Astronomy, University of British Columbia, Vancouver, Canada.; International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, Canada.; Department of Radiology, University of British Columbia, Vancouver, Canada.; Pathology & Laboratory Medicine, University of British Columbia, Vancouver, Canada.
Jazyk: angličtina
Zdroj: Journal of neuroimaging : official journal of the American Society of Neuroimaging [J Neuroimaging] 2020 Jan; Vol. 30 (1), pp. 50-57. Date of Electronic Publication: 2019 Aug 13.
DOI: 10.1111/jon.12659
Abstrakt: Background and Purpose: Acquiring and interpreting quantitative myelin-specific MRI data at an individual level is challenging because of technical difficulties and natural myelin variation in the population. To overcome these challenges, we used multiecho T 2 myelin water imaging (MWI) to create T 2 metric healthy population atlases that depict the mean and variation of myelin water fraction (MWF), and intra- and extracellular water mobility as described by geometric mean T 2 (IEGMT 2 ).
Methods: Cervical cord MWI was performed at 3T on 20 healthy individuals (10M/10F, mean age: 36 years) and 3 relapsing remitting multiple sclerosis (RRMS) participants (1M/2F, age: 39/42/37 years). Anatomical data were collected for the purpose of image segmentation and registration. Atlases were created by coregistering and averaging T 2 metrics from all controls. Voxel-wise z-score maps from 3 RRMS participants were produced to demonstrate the preliminary utility of the MWF and IEGMT 2 atlases.
Results: The average MWF atlas provides a representation of myelin in the spinal cord consistent with well-known spinal cord anatomical characteristics. The IEGMT 2 atlas also depicted structural variations in the spinal cord. Z-score analysis illustrated distinct abnormalities in MWF and IEGMT 2 in the 3 RRMS cases.
Conclusions: Our findings highlight the potential for using a quantitative T 2 relaxation metric atlas to visualize and detect pathology in spinal cord. Our MWF and IEGMT 2 atlases (URL: https://sourceforge.net/projects/mwi-spinal-cord-atlases/) can serve as normative references in the cervical spinal cord for other studies.
(© 2019 by the American Society of Neuroimaging.)
Databáze: MEDLINE
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