Cytocompatible, Injectable, and Electroconductive Soft Adhesives with Hybrid Covalent/Noncovalent Dynamic Network.

Autor: Xu Y; B CUBE Center for Molecular Bioengineering Technische Universität Dresden Tatzberg 41 01307 Dresden Germany., Patsis PA; B CUBE Center for Molecular Bioengineering Technische Universität Dresden Tatzberg 41 01307 Dresden Germany., Hauser S; Helmholtz-Zentrum Dresden-Rossendorf Institute of Radiopharmaceutical Cancer Research Department of Radiopharmaceutical and Chemical Biology Bautzner Landstraße 400 01328 Dresden Germany., Voigt D; Institute for Botany Faculty of Biology School of Science Technische Universität Dresden 01062 Dresden Germany., Rothe R; Helmholtz-Zentrum Dresden-Rossendorf Institute of Radiopharmaceutical Cancer Research Department of Radiopharmaceutical and Chemical Biology Bautzner Landstraße 400 01328 Dresden Germany.; Faculty of Chemistry and Food Chemistry School of Science Technische Universität Dresden Mommsenstraße 66 01062 Dresden Germany., Günther M; Institute for Botany Faculty of Biology School of Science Technische Universität Dresden 01062 Dresden Germany., Cui M; B CUBE Center for Molecular Bioengineering Technische Universität Dresden Tatzberg 41 01307 Dresden Germany., Yang X; Helmholtz-Zentrum Dresden-Rossendorf (HZDR) Institute of Fluid Dynamics Bautzner Landstraße 400 01328 Dresden Germany., Wieduwild R; B CUBE Center for Molecular Bioengineering Technische Universität Dresden Tatzberg 41 01307 Dresden Germany., Eckert K; Helmholtz-Zentrum Dresden-Rossendorf (HZDR) Institute of Fluid Dynamics Bautzner Landstraße 400 01328 Dresden Germany., Neinhuis C; Institute for Botany Faculty of Biology School of Science Technische Universität Dresden 01062 Dresden Germany., Akbar TF; Biotechnology Center Technische Universität Dresden Tatzberg 47/49 01307 Dresden Germany.; Leibniz Institute of Polymer Research Dresden (IPF) Max Bergmann Center of Biomaterials Dresden (MBC) Hohe Str. 6 01069 Dresden Germany., Minev IR; Biotechnology Center Technische Universität Dresden Tatzberg 47/49 01307 Dresden Germany., Pietzsch J; Helmholtz-Zentrum Dresden-Rossendorf Institute of Radiopharmaceutical Cancer Research Department of Radiopharmaceutical and Chemical Biology Bautzner Landstraße 400 01328 Dresden Germany.; Faculty of Chemistry and Food Chemistry School of Science Technische Universität Dresden Mommsenstraße 66 01062 Dresden Germany., Zhang Y; B CUBE Center for Molecular Bioengineering Technische Universität Dresden Tatzberg 41 01307 Dresden Germany.
Jazyk: angličtina
Zdroj: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2019 May 24; Vol. 6 (15), pp. 1802077. Date of Electronic Publication: 2019 May 24 (Print Publication: 2019).
DOI: 10.1002/advs.201802077
Abstrakt: Synthetic conductive biopolymers have gained increasing interest in tissue engineering, as they can provide a chemically defined electroconductive and biomimetic microenvironment for cells. In addition to low cytotoxicity and high biocompatibility, injectability and adhesiveness are important for many biomedical applications but have proven to be very challenging. Recent results show that fascinating material properties can be realized with a bioinspired hybrid network, especially through the synergy between irreversible covalent crosslinking and reversible noncovalent self-assembly. Herein, a polysaccharide-based conductive hydrogel crosslinked through noncovalent and reversible covalent reactions is reported. The hybrid material exhibits rheological properties associated with dynamic networks such as self-healing and stress relaxation. Moreover, through fine-tuning the network dynamics by varying covalent/noncovalent crosslinking content and incorporating electroconductive polymers, the resulting materials exhibit electroconductivity and reliable adhesive strength, at a similar range to that of clinically used fibrin glue. The conductive soft adhesives exhibit high cytocompatibility in 2D/3D cell cultures and can promote myogenic differentiation of myoblast cells. The heparin-containing electroconductive adhesive shows high biocompatibility in immunocompetent mice, both for topical application and as injectable materials. The materials could have utilities in many biomedical applications, especially in the area of cardiovascular diseases and wound dressing.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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