The role of the right prefrontal cortex in recognition of facial emotional expressions in depressed individuals: fNIRS study.

Autor: Manelis A; Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: anna.manelis@gmail.com., Huppert TJ; Center for the Neural Basis of Cognition, Clinical Science Translational Institute, Departments of Radiology and Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA., Rodgers E; Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA., Swartz HA; Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA., Phillips ML; Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA.
Jazyk: angličtina
Zdroj: Journal of affective disorders [J Affect Disord] 2019 Nov 01; Vol. 258, pp. 151-158. Date of Electronic Publication: 2019 Aug 05.
DOI: 10.1016/j.jad.2019.08.006
Abstrakt: Background: Depressed individuals often perceive neutral facial expressions as emotional. Neurobiological underpinnings of this effect remain unclear. We investigated the differences in prefrontal cortical (PFC) activation in depressed individuals vs. healthy controls (HC) during recognition of emotional and neutral facial expressions using functional near infrared spectroscopy (fNIRS).
Method: In Experiment 1, 33 depressed individuals and 20 HC performed the Emotion Intensity Rating task in which they rated intensity of facial emotional expressions. In Experiment 2, a different set of participants (18 depressed individuals and 16 HC) performed the same task while their PFC activation was measured using fNIRS.
Results: Both experiments showed that depressed individuals were slower and less accurate in recognizing neutral, but not happy or fearful, facial emotional expressions. Experiment 2 revealed that lower accuracy for neutral facial emotional expressions was associated with lower right PFC activation in depressed individuals, but not HC. In addition, depressed individuals, compared to HC, had lower right PFC activation during recognition of happy facial expressions.
Limitations: Relatively small sample size CONCLUSIONS: Recognition of neutral facial expressions is impaired in depressed individuals. Greater impairment corresponds to lower right PFC activation during neutral face processing. Recognition of happy facial expressions is comparable for depressed individuals and HC, but the former have significantly lower right PFC activation. Taken together, these findings suggest that the ability of depressed individuals to discriminate neutral and emotional signals in the environment may be affected by aberrant functioning of right PFC.
(Copyright © 2019. Published by Elsevier B.V.)
Databáze: MEDLINE
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