Skin Ultrasound Measurement as a Potential Marker of Bone Quality: A Prospective Pilot Study of Patients undergoing Lumbar Spinal Fusion.

Autor: Salzmann SN; Hospital for Special Surgery, New York, New York., Okano I; Hospital for Special Surgery, New York, New York., Rentenberger C; Hospital for Special Surgery, New York, New York., Winter F; Hospital for Special Surgery, New York, New York., Miller CO; Hospital for Special Surgery, New York, New York., Schadler P; Hospital for Special Surgery, New York, New York., Sax OC; Hospital for Special Surgery, New York, New York., Miller TT; Hospital for Special Surgery, New York, New York., Shue J; Hospital for Special Surgery, New York, New York., Boskey AL; Hospital for Special Surgery, New York, New York., Sama AA; Hospital for Special Surgery, New York, New York., Cammisa FP; Hospital for Special Surgery, New York, New York., Girardi FP; Hospital for Special Surgery, New York, New York., Hughes AP; Hospital for Special Surgery, New York, New York.
Jazyk: angličtina
Zdroj: Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2019 Dec; Vol. 37 (12), pp. 2508-2515. Date of Electronic Publication: 2019 Aug 26.
DOI: 10.1002/jor.24438
Abstrakt: Bone mineral density (BMD) is not the sole predictor of fracture development. Qualitative markers including bone collagen maturity contribute to bone fragility. Bone and related type I collagen containing connective tissues degenerate in parallel fashion. With aging, changes in skin collagen content and quality have been observed that can be detected on ultrasound (US) as a decrease in dermal thickness and an increase in reticular layer echogenicity. We hypothesized that US dermal thickness and echogenicity correlate with bone collagen maturity. Data of 43 prospectively enrolled patients (mean age 61 years, 24 females), who underwent instrumented, posterior lumbar fusion was analyzed. Besides preoperative quantitative computed tomography (QCT) and skin US measurements, intraoperative bone biopsies were obtained and analyzed with Fourier-transform infrared spectroscopy. Among men, there was no correlation between US measurements and collagen maturity. Among women, dermal layer thickness correlated negatively with collagen maturity in trabecular bone of the iliac crest (r = -0.51, p = 0.01) and vertebra (r = -0.59, p = 0.01) as well as in cortical bone of the iliac crest (r = -0.50, p = 0.02) and vertebra (r = -0.50, p = 0.04). In addition, echogenicity correlated positively with collagen maturity in trabecular vertebral bone (r = 0.59, p = 0.01). In both genders, US measurements showed no correlation with QCT BMD. In summary, ultrasound skin parameters are associated with bone quality factors such as collagen maturity, rather than bone quantity (BMD). Ultrasound of the skin may thereby be an easy and accessible take off point for diagnosis of bone collagen maturity and connective tissue degeneration in the future. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2508-2515, 2019.
(© 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.)
Databáze: MEDLINE
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