Transfusion medicine: A research agenda for the coming years.

Autor: Blumberg N; Department of Pathology and Laboratory Medicine (Transfusion Medicine), University of Rochester Medical Center, Rochester, NY, USA. Electronic address: neil_blumberg@urmc.rochester.edu., Cholette JM; Department of Pediatrics, Division of Critical Care, University of Rochester Medical Center, Rochester, NY, USA; Department of Pediatrics, Division of Cardiology, University of Rochester Medical Center, Rochester, NY, USA., Cahill C; Department of Pathology and Laboratory Medicine (Transfusion Medicine), University of Rochester Medical Center, Rochester, NY, USA., Pietropaoli AP; Department of Medicine, Division of Critical Care and Pulmonary, University of Rochester Medical Center, Rochester, NY, USA., Winters S; Department of Pathology and Laboratory Medicine (Transfusion Medicine), University of Rochester Medical Center, Rochester, NY, USA., Phipps R; Department of Pathology and Laboratory Medicine (Transfusion Medicine), University of Rochester Medical Center, Rochester, NY, USA; Department of Medicine, Division of Critical Care and Pulmonary, University of Rochester Medical Center, Rochester, NY, USA., Noronha SA; Department of Pediatrics, Division of Hematology-Oncology, University of Rochester Medical Center, Rochester, NY, USA., Heal JM; Department of Pathology and Laboratory Medicine (Transfusion Medicine), University of Rochester Medical Center, Rochester, NY, USA., Kirkley SA; Department of Pathology and Laboratory Medicine (Transfusion Medicine), University of Rochester Medical Center, Rochester, NY, USA., Fountaine TJ; Department of Pediatrics, Division of Cardiology, University of Rochester Medical Center, Rochester, NY, USA; Department of Medicine, Hematology-Oncology Division,Rochester, NY, USA., Henrichs K; Department of Pathology and Laboratory Medicine (Transfusion Medicine), University of Rochester Medical Center, Rochester, NY, USA., Masel D; Department of Pathology and Laboratory Medicine (Transfusion Medicine), University of Rochester Medical Center, Rochester, NY, USA., Refaai MA; Department of Pathology and Laboratory Medicine (Transfusion Medicine), University of Rochester Medical Center, Rochester, NY, USA; Department of Medicine, Hematology-Oncology Division,Rochester, NY, USA.
Jazyk: angličtina
Zdroj: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis [Transfus Apher Sci] 2019 Oct; Vol. 58 (5), pp. 698-700. Date of Electronic Publication: 2019 Aug 06.
DOI: 10.1016/j.transci.2019.08.015
Abstrakt: The important scientific and clinical advances of the last century in transfusion medicine include methods for avoiding hemolytic transfusion reactions and preventing transmission of viral infectious diseases. The next great clinical advances will require improving the efficacy and safety of transfusions, as well as acknowledgement of the now proven serious complications of transfusion, including nosocomial infection, thrombosis, inflammation and multi-organ failure. Possible strategies include (1) universal leukoreduction to mitigate transfusion immunomodulation effects and improve storage conditions, (2) minimizing transfusion of ABO incompatible antibodies and cellular/soluble antigens, (3) substituting use of safer solutions for normal saline during apheresis, component infusion and washing (4) new techniques to improve the efficacy and safety of blood components, including improved storage solutions/conditions, supernatant removal by washing, and rejuvenation and (5) maximizing the risk to benefit ratio of transfusions by employing more restrictive and physiologic indications for transfusion (including patient blood management) and improving clinical decision making through novel laboratory and bedside tests such as thromboelastography.
(Copyright © 2019. Published by Elsevier Ltd.)
Databáze: MEDLINE
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