Micro RNA-192 Is Negatively Associated With Cardiovascular Events Among Wait-Listed Potential Kidney Transplant Recipients on Hemodialysis Over a 5-year Follow-up Period.

Autor: Hassan MG; Department of Nephrology & Department of Internal Medicine, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt., Morise F; Department of Nephrology & Department of Internal Medicine, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt., Osman NA; Department of Nephrology, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt., Salam LA; Genome Unit, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt., Yehia H; Department of Cardiology, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt., Hamdi M; Department of Critical Care, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt., El Husseiny NM; Department of Internal Medicine, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt., NasrAllah MM; Department of Nephrology, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt. Electronic address: mmnasrallah@kasralainy.edu.eg.
Jazyk: angličtina
Zdroj: Transplantation proceedings [Transplant Proc] 2019 Sep; Vol. 51 (7), pp. 2237-2240. Date of Electronic Publication: 2019 Aug 06.
DOI: 10.1016/j.transproceed.2019.02.044
Abstrakt: Background: Patients with chronic renal disease are susceptible to accelerated vascular calcification and cardiovascular morbidity and mortality. Micro RNAs (miRNAs) have been linked to the pathogenesis of cardiovascular diseases in the general population.
Aim: This study was carried out to evaluate the link between miRNA 192 and vascular calcification, pre-existing as well as newly occurring major adverse cardiovascular events, and mortality among hemodialysis patients who are also considered to be potential kidney transplant recipients.
Methods: We screened 64 potential transplant recipients on hemodialysis at our university hospital. Pre-existing overt cardiovascular disease was recorded; new adverse cardiovascular events and all causes of death over an observational period of 5 years were prospectively followed. Vascular calcification was measured in the aorta using computerized tomography scans, and micro RNA 192 was measured.
Results: The final study population included 55 patients followed for 63 months. Micro RNA 192 was significantly lower in patients who had preexisting cardiovascular disease (P = .015) as well and in all patients who had experienced any event by the end of the observational period (P = .012). A multiregression analysis model including micro RNA, age, dialysis vintage, intradialytic hypotension, vascular calcification, diabetes, systolic blood pressure, and smoking found the only independently correlating factor to cardiovascular events in this model to be micro RNA (β = -0.286, P = .05).
Conclusions: MiRNA 192 levels are significantly lower among patients experiencing cardiovascular events while on hemodialysis awaiting kidney transplantation.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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