The Prevalence and Case-Fatality Rates of Post-Neonatal Tetanus in a Population of Hospitalized Nigerian Children: An 8-Year Retrospective Review.

Autor:	Okike CO; Department of Paediatrics, Federal Medical Centre Asaba, 1033 Asaba, Delta, Nigeria., Muoneke UV; Department of Paediatrics, College of Medicine, University of Nigeria, Enugu Campus, 40001 Enugu, Enugu State, Nigeria., Uwaezuoke SN; Department of Paediatrics, College of Medicine, University of Nigeria, Enugu Campus, 40001 Enugu, Enugu State, Nigeria., Mbagwu EN; Department of Paediatrics, Federal Medical Centre Asaba, 1033 Asaba, Delta, Nigeria., Onyeka-Okite E; Department of Paediatrics, Federal Medical Centre Asaba, 1033 Asaba, Delta, Nigeria.
Jazyk:	angličtina
Zdroj:	Journal of tropical pediatrics [J Trop Pediatr] 2020 Apr 01; Vol. 66 (2), pp. 201-209.
DOI:	10.1093/tropej/fmz054
Abstrakt:	Background: Although tetanus is a vaccine-preventable disease, reports indicate that it remains a significant cause of morbidity and mortality in both neonatal and post-neonatal periods especially in most developing countries. Aim: This study aimed to determine the prevalence and case fatality rates of post-neonatal tetanus among children managed at the Federal Medical Centre Asaba, Delta State, Nigeria over 8 years. Method: The study was a retrospective review of the records of the children above 1 month of age admitted into Federal Medical Centre, Asaba, with a clinical diagnosis of tetanus from January 2008 to May 2016. Data analysis was conducted on descriptive and inferential statistics using Statistical Package for Social Sciences version 22.0. Mean, standard deviation and other relevant parameters were calculated. Level of significance was set at p < 0.05. Results: During the study period, 32 out of 3693 admitted Paediatric patients had post-neonatal tetanus: giving a prevalence rate of 0.9%. The male : female ratio was 1.9 : 1 and patients' ages ranged from 2 to 15 years with a mean age 8.9 ± 3.1 years. Twenty-nine percent of them had complete immunization during infancy, but none had booster doses. Also, 60.9% of them presented with lower limb injuries as the portal of entry. Over 17.4% of the patients had very severe tetanus. Of the 32 patients studied, 62.5% resided in the neighbouring rural communities, while 50.0% were admitted for ≤10 days. The calculated case fatality rate was 50%. Conclusion: The prevalence and case fatality rates of post-neonatal tetanus are still relatively high in this clime. Given the prevalent nature of the disease in children aged 5 years and above, there is a need to include the booster doses of tetanus toxoid in the country's National Programme on Immunization schedule. (© The Author(s) [2019]. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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