N-acetylcysteine prevents orchiectomy-induced osteoporosis by inhibiting oxidative stress and osteocyte senescence.

Autor:	Chen L; Department of Anatomy, Histology and Embryology, Nanjing Medical University Nanjing 211166, Jiangsu, China.; Key Laboratory for Aging and Disease, Histology and Embryology, Nanjing Medical University Nanjing 211166, Jiangsu, China., Wang G; Department of Orthopedics, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, Jiangsu, China., Wang Q; Department of Orthopedics, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, Jiangsu, China., Liu Q; Department of Orthopedics, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, Jiangsu, China., Sun Q; Department of Orthopedics, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, Jiangsu, China., Chen L; Department of Anatomy, Histology and Embryology, Nanjing Medical University Nanjing 211166, Jiangsu, China.; Key Laboratory for Aging and Disease, Histology and Embryology, Nanjing Medical University Nanjing 211166, Jiangsu, China.
Jazyk:	angličtina
Zdroj:	American journal of translational research [Am J Transl Res] 2019 Jul 15; Vol. 11 (7), pp. 4337-4347. Date of Electronic Publication: 2019 Jul 15 (Print Publication: 2019).
Abstrakt:	Oxidative stress is associated with many diseases and has been found to induce DNA damage and cellular senescence. Numerous evidences support the detrimental effects of oxidative stress or cellular senescence on skeletal homeostasis. N-acetylcysteine (NAC) is a powerful antioxidant. However, it is unclear whether NAC can suppress orchiectomy (ORX)-induced osteoporosis by inhibiting oxidative stress and osteocyte senescence. In this study, ORX mice were supplemented with/without NAC, and were compared with each other and with sham-operated mice. Our results showed that NAC could prevent ORX-induced osteoporosis by inhibiting oxidative stress, DNA damage, osteocyte senescence and senescence-associated secretory phenotype (SASP), subsequently stimulating osteoblastic bone formation and inhibiting osteoclastic bone resorption. The results from this study suggest that NAC could be considered as a potential therapeutic agent for prevention and treatment of osteoporosis caused by testosterone deficiency. Competing Interests: None.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu