Cytotoxic, fungicidal nucleosides from blue green algae belonging to the Scytonemataceae.

Autor: Stewart JB; Department of Chemistry, University of Hawaii, Honolulu 96822., Bornemann V, Chen JL, Moore RE, Caplan FR, Karuso H, Larsen LK, Patterson GM
Jazyk: angličtina
Zdroj: The Journal of antibiotics [J Antibiot (Tokyo)] 1988 Aug; Vol. 41 (8), pp. 1048-56.
DOI: 10.7164/antibiotics.41.1048
Abstrakt: Tubercidin, toyocamycin, and the corresponding 5'-alpha-D-glucopyranose derivatives of the nucleosides are frequently responsible for much of the cytotoxicity and antimycotic activity associated with extracts of cultured cyanophytes belonging to the family Scytonemataceae. The 5'-alpha-D-glucopyranoses of tubercidin and toyocamycin, for example, are the major cytotoxic and fungicidal nucleosides in Fijian Plectonema radiosum and Hawaiian Tolypothrix tenuis, respectively.
Databáze: MEDLINE