Detection and Concentration of Plasma Aflatoxin is Associated with Detection of Oncogenic Human Papillomavirus in Kenyan Women.

Autor: Zhang J; Department of Epidemiology, Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA., Orang'o O; Department of Reproductive Health, Moi University, Eldoret, Kenya., Tonui P; Department of Reproductive Health, Moi University, Eldoret, Kenya., Tong Y; Department of Biostatistics, Indiana University School of Medicine and Fairbanks School of Public Health, Indianapolis, IN, USA., Maina T; Department of Molecular Biology, Maseno University, Kenya., Kiptoo S; Academic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya., Muthoka K; Academic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya., Groopman J; Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA., Smith J; Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA., Madeen E; Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA., Ermel A; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Loehrer P; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Brown DR; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Jazyk: angličtina
Zdroj: Open forum infectious diseases [Open Forum Infect Dis] 2019 Sep 02; Vol. 6 (9).
DOI: 10.1093/ofid/ofz354
Abstrakt: Background: Cervical cancer is common in Kenyan women. Cofactors in addition to infection with oncogenic human papillomavirus (HPV) are likely to be important in causing cervical cancer, as only a small percentage of HPV-infected women will develop this malignancy. Kenyan women are exposed to dietary aflatoxin, a potent carcinogen and immunosuppressive agent, which may be such a co-factor.
Methods: Demographics, behavioral data, plasma, and cervical swabs were collected from 88 HIV-uninfected Kenyan women without cervical dysplasia. HPV detection was compared between women with or without plasma AFB1-lys and evaluated in relation to AFB1-lys concentration.
Results: Valid HPV testing results were available for 86 women (mean age 34.0 years); 49 women (57.0%) had AFB1-lys detected and 37 (43.0%) had none. AFB1-lys detection was not associated with age, being married, having more than secondary school education, home ownership, living at a walking distance to health care ≥60 minutes, number of lifetime sex partners, or age of first sex. AFB1-lys detection and plasma concentrations were associated with detection of oncogenic HPV types.
Conclusions: AFB1-lys-positivity and higher plasma AFB1-lys concentrations were associated with higher risk of oncogenic HPV detection in cervical samples from Kenya women. Further studies are needed to determine if aflatoxin interacts with HPV in a synergistic manner to increase the risk of cervical cancer.
(© The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze: MEDLINE
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