MicroRNA-122 in patients with hepatitis B and hepatitis B virus-associated hepatocellular carcinoma.
| Autor: | Mahmoudian-Sani MR; Research Center of Thalassemia and Hemoglobinopathy, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Asgharzade S; Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran., Alghasi A; Research Center of Thalassemia and Hemoglobinopathy, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Saeedi-Boroujeni A; Abadan School of Medical Sciences, Abadan, Iran., Adnani Sadati SJ; Department of Microbiology & Immunology, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran., Moradi MT; Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of gastrointestinal oncology [J Gastrointest Oncol] 2019 Aug; Vol. 10 (4), pp. 789-796. |
| DOI: | 10.21037/jgo.2019.02.14 |
| Abstrakt: | Hepatitis B virus (HBV) infection is known as a serious problem in the domain of public health and approximately 350 million people across the world are affected with this infectious disease. As well, microRNAs are recognized as a type of small non-coding RNAs that can be widely used as a diagnostic biomarker and prognosis method of special diseases. In this respect, microRNA-122 or miR-122 can play a significant role in the pathogenesis of several hepatic diseases. Given the importance of microRNA-122 in the liver as well as its pathology, this study focused on the potential functions of microRNA-122 in pathogenesis, diagnosis, and treatment of HBV infection. In this regard, the findings of previous studies had indicated that expression of microRNA-122 in patients with HBV infection could be significantly deregulated. The results of this study were consistent with the idea that diagnosis and treatment of this infectious disease using microRNA-122 could be an efficient method. Competing Interests: Conflicts of Interest: The authors have no conflicts of interest to declare. |
| Databáze: | MEDLINE |
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