Neonatal jaundice in association with autism spectrum disorder and developmental disorder.

Autor: Cordero C; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA. c.cordero@med.miami.edu., Schieve LA; National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA., Croen LA; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA., Engel SM; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Maria Siega-Riz A; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.; Department of Family, Community & Mental Health Systems, University of Virginia, Charlottesville, VA, USA., Herring AH; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.; Department of Statistical Science, Duke University, Durham, NC, USA., Vladutiu CJ; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Seashore CJ; Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA., Daniels JL; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2020 Feb; Vol. 40 (2), pp. 219-225. Date of Electronic Publication: 2019 Aug 06.
DOI: 10.1038/s41372-019-0452-4
Abstrakt: Objective: To examine the association between neonatal jaundice and autism spectrum disorder (ASD) and non-ASD developmental disorder (DD).
Study Design: We analyzed data from the Study to Explore Early Development, a US multisite, case-control study conducted from 2007 to 2011. Developmental assessment classified children aged 2-5 years into: ASD (n = 636), DD (n = 777), or controls (POP; n = 926). Neonatal jaundice (n = 1054) was identified from medical records and maternal interviews. We examined associations between neonatal jaundice and ASD and DD using regression models to obtain adjusted odds ratios (aOR).
Results: Our results showed interaction between gestational age and neonatal jaundice. Neonatal jaundice was associated with ASD at 35-37 weeks (aOR = 1.83, 95%CI 1.05, 3.19), but not ≥38 weeks gestation (aOR = 0.97, 95%CI 0.76, 1.24). Similar results were observed with DD.
Conclusions: Further exploration of timing and severity of neonatal jaundice and ASD/DD is warranted.
Databáze: MEDLINE
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