| Autor: |
Róvero Costa M; Medical School, São Paulo State University (Unesp), Botucatu 18618-687, Brazil. marianerovero@gmail.com., Leite Garcia J; Medical School, São Paulo State University (Unesp), Botucatu 18618-687, Brazil., Cristina Vágula de Almeida Silva C; Medical School, São Paulo State University (Unesp), Botucatu 18618-687, Brazil., Junio Togneri Ferron A; Medical School, São Paulo State University (Unesp), Botucatu 18618-687, Brazil., Valentini Francisqueti-Ferron F; Medical School, São Paulo State University (Unesp), Botucatu 18618-687, Brazil., Kurokawa Hasimoto F; Medical School, São Paulo State University (Unesp), Botucatu 18618-687, Brazil., Schmitt Gregolin C; Medical School, São Paulo State University (Unesp), Botucatu 18618-687, Brazil., Henrique Salomé de Campos D; Medical School, São Paulo State University (Unesp), Botucatu 18618-687, Brazil., Roberto de Andrade C; School of Dentistry, São Paulo State University (Unesp), Araraquara 14800-901, Brazil., Dos Anjos Ferreira AL; Medical School, São Paulo State University (Unesp), Botucatu 18618-687, Brazil., Renata Corrêa C; Medical School, São Paulo State University (Unesp), Botucatu 18618-687, Brazil., Moreto F; Medical School, São Paulo State University (Unesp), Botucatu 18618-687, Brazil. |
| Abstrakt: |
Background : The higher consumption of fat and sugar are associated with obesity development and its related diseases such as non-alcoholic fatty liver disease (NAFLD). Lycopene is an antioxidant whose protective potential on fatty liver degeneration has been investigated. The aim of this study was to present the therapeutic effects of lycopene on NAFLD related to the obesity induced by a hypercaloric diet. Methods : Wistar rats were distributed in two groups: Control (Co, n = 12) and hypercaloric (Ob, n = 12). After 20 weeks, the animals were redistributed into the control group (Co, n = 6), control group supplemented with lycopene (Co+Ly, n = 6), obese group (Ob, n = 6), and obese group supplemented with lycopene (Ob+Ly, n = 6). Ob groups also received water + sucrose (25%). Animals received lycopene solution (10 mg/kg/day) or vehicle (corn oil) via gavage for 10 weeks. Results : Animals which consumed the hypercaloric diet had higher adiposity index, increased fasting blood glucose, hepatic and blood triglycerides, and also presented in the liver macro and microvesicular steatosis, besides elevated levels of tumor necrosis factor-α (TNF-α). Lycopene has shown therapeutic effects on blood and hepatic lipids, increased high-density lipoprotein cholesterol (HDL), mitigated TNF-α, and malondialdehyde (MDA) and further improved the hepatic antioxidant capacity. Conclusion : Lycopene shows therapeutic potential to NAFLD. |
