Usefulness of fecal calprotectin as a biomarker of microscopic colitis in a cohort of patients with chronic watery diarrhoea of functional characteristics.

Autor: Batista L; Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Terrassa, Barcelona, Spain., Ruiz L; Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Terrassa, Barcelona, Spain., Ferrer C; Department of Pathology, Hospital Universitari Mutua Terrassa, Terrassa, Barcelona, Spain., Zabana Y; Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Terrassa, Barcelona, Spain; Centro de Investigaciones Biomédicas en Red de enfermedades hepáticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain., Aceituno M; Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Terrassa, Barcelona, Spain; Centro de Investigaciones Biomédicas en Red de enfermedades hepáticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain., Arau B; Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Terrassa, Barcelona, Spain., Andújar X; Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Terrassa, Barcelona, Spain., Esteve M; Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Terrassa, Barcelona, Spain; Centro de Investigaciones Biomédicas en Red de enfermedades hepáticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain., Fernández-Bañares F; Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Terrassa, Barcelona, Spain; Centro de Investigaciones Biomédicas en Red de enfermedades hepáticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: ffbanares@mutuaterrassa.es.
Jazyk: angličtina
Zdroj: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2019 Dec; Vol. 51 (12), pp. 1646-1651. Date of Electronic Publication: 2019 Aug 02.
DOI: 10.1016/j.dld.2019.07.002
Abstrakt: Background: Information on the use of fecal markers in microscopic colitis screening is limited.
Aim: To evaluate the risk variables associated with a diagnosis of microscopic colitis including fecal calprotectin.
Methods: Patients submitted for a colonoscopy due to chronic watery diarrhea fulfilling criteria of functional disease were evaluated. Colonic mucosa was normal but mild erythema and edema was allowed. Fecal calprotectin was analyzed. A logistic regression was used to evaluate variables associated with both raised fecal calprotectin and a diagnosis of microscopic colitis.
Results: 94 patients were included, 30 were diagnosed with microscopic colitis and 64 made up the control group. Median calprotectin levels were 175 (IQR, 59-325) for the microscopic colitis and 28 (IQR, 16-111) for the control group (p < 0.001). The optimal cut-off for fecal calprotectin was >100 μg/g (AUC, 0.73), with 67% sensitivity and 75% specificity. The number of drugs used ≥3 (OR, 3.9; CI, 1.4-10.4) and microscopic colitis diagnosis (OR, 6; CI, 2.2-16.3) were associated with raised calprotectin levels. Age >60 years (OR, 3.8; CI, 1.4-10.1) and calprotectin levels (OR, 5.3; CI, 2-14.1) were associated with a risk of microscopic colitis.
Conclusions: Elevated fecal calprotectin concentrations are often seen in microscopic colitis, and may be helpful in the diagnosis of women over 60 with chronic watery diarrhea.
(Copyright © 2019 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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