Rapid Susceptibility Testing Methods.
| Autor: | Smith KP; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, 3 Blackfan Circle-CLS624, Boston, MA 02115, USA., Kirby JE; Clinical Microbiology, Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue-YA309, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: jekirby@bidmc.harvard.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Clinics in laboratory medicine [Clin Lab Med] 2019 Sep; Vol. 39 (3), pp. 333-344. Date of Electronic Publication: 2019 Jun 12. |
| DOI: | 10.1016/j.cll.2019.04.001 |
| Abstrakt: | With emerging antimicrobial resistance, rapid antimicrobial susceptibility testing (AST) is needed to provide early definitive therapeutic guidance to optimize patient outcome. Genotypic methods are fast, but can identify only a subset of known resistance elements. Phenotypic methods determine clinically predictive minimal inhibitory concentrations and include very sensitive optical and biophysical methods to detect changes in replication or physiology of pathogens in response to antibiotics. For the potential of rapid AST to be fully realized, results must be linked with robust decision support solutions that will implement therapeutic changes in real time. (Copyright © 2019 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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