Cognitive Deficits in Older Adults With Psychotic Depression: A Meta-Analysis.

Autor:	Vermeulen T; Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp (TV, LVD, BGS, and RCvdM), Antwerp, Belgium. Electronic address: Tom.vermeulen@uantwerpen.be., Lauwers T; Scientific Initiative for Neuropsychiatric and Psychopharmacological Studies, University Psychiatric Hospital Duffel (TL, LVD, and BGS), Duffel, Antwerp, Belgium., Van Diermen L; Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp (TV, LVD, BGS, and RCvdM), Antwerp, Belgium; Scientific Initiative for Neuropsychiatric and Psychopharmacological Studies, University Psychiatric Hospital Duffel (TL, LVD, and BGS), Duffel, Antwerp, Belgium., Sabbe BG; Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp (TV, LVD, BGS, and RCvdM), Antwerp, Belgium; Scientific Initiative for Neuropsychiatric and Psychopharmacological Studies, University Psychiatric Hospital Duffel (TL, LVD, and BGS), Duffel, Antwerp, Belgium., van der Mast RC; Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp (TV, LVD, BGS, and RCvdM), Antwerp, Belgium; University Medical Centre Leiden, University of Leiden, (RCvdM and EJG), Leiden, the Netherlands., Giltay EJ; University Medical Centre Leiden, University of Leiden, (RCvdM and EJG), Leiden, the Netherlands.
Jazyk:	angličtina
Zdroj:	The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry [Am J Geriatr Psychiatry] 2019 Dec; Vol. 27 (12), pp. 1334-1344. Date of Electronic Publication: 2019 Jul 23.
DOI:	10.1016/j.jagp.2019.07.011
Abstrakt:	A major depressive disorder with psychotic features, that is, psychotic depression (PD), is often accompanied by cognitive deficits, particularly in older patients. We aimed to assess to what extent various cognitive domains are affected in older patients with PD compared to those with nonpsychotic depression (NPD). Therefore, a systematic search was conducted in Medline, Embase, Web of Science, the Cumulative Index to Nursing and Allied Literature (CINAHL), Google Scholar, and Cochrane for all relevant studies. Hereafter, we conducted a meta-analysis of seven studies on cognitive deficits in older adults (55+ years), comparing patients with PD and patients with NPD. Compared to patients with NPD, those with PD not only showed a significantly poorer performance on overall cognitive function, with a Hedges' g effect size of -0.34 (95% confidence interval: -0.56; -0.12; p = 0.003), but also on nearly all separate cognitive domains, with Hedges' g effect sizes ranging from -0.26 to -0.64 (all p's <0.003), of which attention was most adversely affected. Verbal fluency showed no significant effect, although this analysis may have been underpowered. The funnel plot suggested no significant publication bias (Egger test intercept: -2.47; 95% confidence interval: -5.50; 0.55; p = 0.09). We conclude that older patients with PD show more cognitive deficits on all cognitive domains, except for verbal fluency, compared to patients with NPD. It is crucial that clinicians and researchers take cognitive deficits into consideration in older adults with PD. (Copyright © 2019 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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