Effects of experimental intracerebral ventricular injection of amyloid beta peptide (1-42) aggregates on daily rhythms of Aβ-degrading enzymes in the hippocampus: Relevance to Alzheimer's disease pathophysiology.

Autor: Castro A; Laboratory of Chronobiology, Multidisciplinary Institute of Biological Research-San Luis (IMIBIO-SL), National Council of Science and Technology (CONICET), National University of San Luis (UNSL). Av Ejército de los Andes N°950, D5700HHW, San Luis, Argentina., Coria-Lucero C; Laboratory of Chronobiology, Multidisciplinary Institute of Biological Research-San Luis (IMIBIO-SL), National Council of Science and Technology (CONICET), National University of San Luis (UNSL). Av Ejército de los Andes N°950, D5700HHW, San Luis, Argentina., Anzulovich A; Laboratory of Chronobiology, Multidisciplinary Institute of Biological Research-San Luis (IMIBIO-SL), National Council of Science and Technology (CONICET), National University of San Luis (UNSL). Av Ejército de los Andes N°950, D5700HHW, San Luis, Argentina. Electronic address: acanzu@unsl.edu.ar., Navigatore-Fonzo L; Laboratory of Chronobiology, Multidisciplinary Institute of Biological Research-San Luis (IMIBIO-SL), National Council of Science and Technology (CONICET), National University of San Luis (UNSL). Av Ejército de los Andes N°950, D5700HHW, San Luis, Argentina. Electronic address: lnavigatore@unsl.edu.ar.
Jazyk: angličtina
Zdroj: Pathophysiology : the official journal of the International Society for Pathophysiology [Pathophysiology] 2019 Sep - Dec; Vol. 26 (3-4), pp. 281-287. Date of Electronic Publication: 2019 Jul 29.
DOI: 10.1016/j.pathophys.2019.07.003
Abstrakt: One of the main pathological features in the Alzheimer disease (AD) is the presence of senile plaques, primarily composed of Aβ peptide aggregates, in cortex and hippocampus. AD late onset, which constitutes 90% of cases, could be mainly attributable to deficiencies in the clearance of the Aß peptide. Here we show that expression of Aβ-degrading enzymes varies on a daily basis in the hippocampus. Interestingly, an intracerebroventricular injection of Aβ aggregates modified temporal patterns of Aβ-degrading proteases, as well as clock proteins (BMAL1 and RORα) and antioxidant enzymes (CAT and GPx) daily rhythms. Our findings showed that the increase of Aβ leads to the alteration of the enzymes involved in the clearance, and, consequently, to an increase of oxidative stress and alteration of the cellular redox state, affecting the functioning of the endogenous clock and daily rhythms of BMAL1, RORα and their target genes, in this disease.
Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest. The authors are solely responsible for the contents and writing of the paper.
(Copyright © 2019. Published by Elsevier B.V.)
Databáze: MEDLINE
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