The Transcription Factor PLZF Is Necessary for the Development and Function of Mouse Basophils.

Autor:	Zhang S; Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901.; Rutgers Graduate School of Biomedical Sciences, Piscataway, NJ 08854., Vieth JA; Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901., Krzyzanowska A; Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901.; Rutgers Graduate School of Biomedical Sciences, Piscataway, NJ 08854., Henry EK; Department of Medicine, Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07103; and., Denzin LK; Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901.; Rutgers Graduate School of Biomedical Sciences, Piscataway, NJ 08854.; Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901., Siracusa MC; Department of Medicine, Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07103; and., Sant'Angelo DB; Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901; santandb@rwjms.rutgers.edu.; Rutgers Graduate School of Biomedical Sciences, Piscataway, NJ 08854.; Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901.
Jazyk:	angličtina
Zdroj:	Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2019 Sep 01; Vol. 203 (5), pp. 1230-1241. Date of Electronic Publication: 2019 Jul 31.
DOI:	10.4049/jimmunol.1900068
Abstrakt:	Basophils are innate immune cells associated with type 2 immunity, allergic reactions, and host defense against parasite infections. In this study, we show that the transcription factor PLZF, which is known for its essential role in the function and development of several innate lymphocyte subsets, is also important for the myeloid-derived basophil lineage. PLZF-deficient mice had decreased numbers of basophil progenitors in the bone marrow and mature basophils in multiple peripheral tissues. Functionally, PLZF-deficient basophils were less responsive to IgE activation and produced reduced amounts of IL-4. The altered function of basophils resulted in a blunted Th2 T cell response to a protein allergen. Additionally, PLZF-deficient basophils had reduced expression of the IL-18 receptor, which impacted migration to lungs. PLZF, therefore, is a major player in controlling type 2 immune responses mediated not only by innate lymphocytes but also by myeloid-derived cells. (Copyright © 2019 by The American Association of Immunologists, Inc.)
Databáze:	MEDLINE
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